摘要
目的分析肾移植术后患者肝炎复发的原因,并探讨可能减少复发的办法。方法观察肾移植术后肝炎复发的8例住院患者,其病毒标志物变化及应用药物、药物浓度、疗程和预后。结果肾移植术后肝炎复发、肝功能衰竭的主要原因可能与免疫抑制后病毒活动以及药物毒性有关。结论对移植术后肝炎复发患者定期监测肝功能、药物浓度和HBV-DNA、HCV-RNA等病毒标志物的变化,并根据肝功能情况适当调整免疫抑制剂的药量,及时加用抗病毒药物,对及时发现病情变化、避免肝功能衰竭是非常重要的。
Objective Analyse the course of the hepatitis relapse in renal transplant recipients and discuss the possible means of decreasing recurrence. Methods Virus signs＇ changes, drug concentration, period of treatment and prognosis were observed in those renal transplant recipients in hospital. Results The possible courses of hepatitis recurrence and liver dysfunction after renal transplantation lies in viral replication after immuno-suppression and medical toxicity. Conclusion Basing on liver function, medical concentration, and HBV-DNA, HCV-RNA termly measured, the quantity of immunodepressor should be properly regulated, anti-viral medicine should be added in time. It is very important for finding state of an illness changing and avoiding liver dysfunction.
出处
《胃肠病学和肝病学杂志》
CAS
2006年第6期606-608,共3页
Chinese Journal of Gastroenterology and Hepatology
关键词
肾移植
肝炎
肝功能衰竭
Kidney transplantation
Hepatitis
Liver dysfunction
