摘要
目的观察神经节苷脂（GMI）治疗急性脑梗死的疗效。方法将60例急性脑梗死患者随机分为GMI组和对照组，在同时给予常规治疗的基础上，分别采用GMI40mg或胞二磷胆碱0．75g加入250ml生理盐水中静脉滴注，每日1次，共2周；观察两组患者治疗前后神经功能缺损程度评分（NDS）及日常生活活动量表（ADL）评分的变化及不良反应。结果治疗后GMI组及对照组NDS及ADL评分与治疗前相比均有显著改善（P〈0．05～0．01）；GMI组改善程度与对照组相比差异有极显著性（均P〈0．01）。两组均未发现明显不良反应。结论GMI治疗急性脑梗死疗效显著。
Objective To investigate the therapeutic effect of Ganglioside （ GM 1 ） on acute cerebral infarction. Methods 60 cases with acute cerebral infarction were divided into two groups randomly. At the basic of routin treatment for the twe gyoups, GMI group was treated with GMI 40 mg/d for 14 days and control group was treated with Citicoline 0. 75 g/d for 14 days . The neurological deficit scores （NDS） , activities of daily living （ADL） and adverse reactions were evaluated. Results After treatment, the scores of NDS and ADL were singnificantly decreased in twe groups than before treatment （ P 〈 0.05 - 0. 01 ）, and GM 1 group were much better than control group （ all P 〈 0. 01 ）. There was no obvious adverse reaction in twe groups. Conclusion The therapeutic effect of GMI on acute cerebral infarction is obvious.
出处
《临床神经病学杂志》
CAS
北大核心
2006年第6期458-459,共2页
Journal of Clinical Neurology
关键词
脑梗死
神经节苷脂
cerebral infarction
Ganglioside
