急性脑梗死患者血小板-白细胞聚集体的变化被引量：17

Changes of platelet-leukocyte aggregations in patients with acute cerebral infarction

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摘要目的探讨急性脑梗死患者血小板-白细胞聚集体(PLA)的变化,及其与血浆C反应蛋白(CRP)、血小板聚集率(PAgT)的关系。方法对46例脑梗死患者(脑梗死组)和24例年龄、性别相配的非脑血管病患者(对照组)进行PLA、CRP和PAgT的检测。结果脑梗死组血小板-单核细胞聚集体(PMA)、PAgT和CRP分别为(13.00±0.76)%、(59.46±3.07)%和(9.39±1.28)mg/L,对照组分别为(6.55±0.29)%、(39.38±5.42)%和(2.37±0.46)mg/L,两组间差异有极显著性(均P<0.01);脑梗死组PLA、血小板-中性粒细胞聚集体(PNA)和血小板-淋巴细胞聚集体(PLyA)高于对照组,但两组间差异无显著性。脑梗死组PMA与CRP和PAgT呈极显著正相关(r=0.390、0.500,均P<0.01)。结论脑梗死急性期患者的炎症反应和血小板活化水平显著增高。 Objective To investigate the changes of platelet-leukocyte aggregations （ PLA ） in patients with acute cerebral infarction and its relationship with C-reactive protein （CRP） and platelet aggregation rate （PAgT）. Methods The PLA, CRP and PAgT were measured in 46 patients with acute cerebral infarction （CI group） and in 24 patients without cerebral vascular diseases （ control group）. Results The platelet-monocyte aggregations （ PMA）, PAgT and CRP in CI group were （（ 13.00 ± 0. 76 ） %, （ 59.46 ±3.07 ） %, （ 9. 39±1.28 ） mg/L, respectively, however, there were （ 6. 55±0. 29 ） %, （ 39. 38± 5.42 ） % , （ 2. 37±0. 46 ） mg/L respectively in control group. There were significant differences between the two groups （all P〈 0.01 ）. The PLA, platelet-neutrocyte aggregations （PNA） and platelet-lymphocyte aggregations （PIyA） in CI group were higher than those in control group. But the differences were not significant . The PMA in CI group was positively correlated with CRP and PAgT （ r = 0. 390, 0. 500,all P 〈 0.01 ）. Conclusion The platelet activation and inflammatory response increase in acute phase of CI.

作者王引明刘春风冯萍罗蔚锋

机构地区苏州大学附属第二医院神经内科苏州大学附属第二医院检验中心

出处《临床神经病学杂志》 CAS 北大核心 2006年第6期408-410,共3页 Journal of Clinical Neurology

关键词脑梗死血小板-白细胞聚集体 C反应蛋白血小板聚集率 cerebral infarction platelet-leukocyte aggregations C-reaction protein platelet aggregation rate

分类号 R743.33 [医药卫生—神经病学与精神病学]

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