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骨桥蛋白:一种新的肿瘤标志物 被引量:8

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摘要 骨桥蛋白(OPN)是一富含精氨酸-甘氨酸-天冬氨酸(RGD)序列的磷酸化糖蛋白,参与细胞信号转导,促进细胞粘附和迁移,并与肿瘤细胞的生长、侵袭、转移密切相关,近年被认为是一新的肿瘤标志物。现就OPN的生物学特点及在肿瘤转移中所起作用进展作一综述。
出处 《国际检验医学杂志》 CAS 2006年第12期1109-1111,共3页 International Journal of Laboratory Medicine
基金 浙江省卫生厅青年基金项目(2003QN017)
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  • 1Wai PY, Kuo PC. The role of Osteopontin in tumor metastasis. J Surg Res, 2004, 121(2):228-241.
  • 2Yeatman TJ, Chambers AF. Osteopontin and colon cancer progression. Clin Exp Metastasis, 2003, 20(1): 85-90.
  • 3Hirama M, Takahashi F. Takahashi K, et al. Osteopontin overproduced by tumor cells acts as a potenl angiogenic factor contributing to tumor growth, Cancer Lett, 2003, 198(1): 107-117.
  • 4Geissinger E, Weisser C, Fischer P, et al. Autocrine stimulation by osteoponlin contributes to antiapoptotic signalling of melanocytes in dermal collagen. Cancer Res, 2002, 62(16):4820-4828.
  • 5Coppola D, Szabo M, Boulware D, et al. Correlation of osteolpontin protein expression and pathological stage across a wide variety of tumor histologies. Clin Cancer Res,2004, 10(1 Pt 1):184-190.
  • 6Tuck AB, Hota C, Chambers AF. Osteopontin(OPN)-induced increase in human mammary epilhelial cell invasiveness is urokinase(uPA)-dependent. Breast Cancer Res Treat, 2001, 70 ( 3 ) : 197-204.
  • 7Takano S, Tsuboi K, Tomono Y, et al, Tissue factor, osteopon-tin, alphavbeta3 integrin expression in microvasculature of gliomas associated with vascular endothelial growth factor expression. Br J Cancer, 2000, 82(12): 1967-1973.
  • 8Schorge JO, Drake RD, Lee H, et al, Osteopontin as an adjunct to CA125 in detecting recurrent ovarian cancer. Clin Cancer Res,2004, 10(10): 3474-3478.
  • 9Wong TS, Kwong DL, Sham J, et al. Elevation of plasma osteopontin level in patients with undifferentiated nasopharyngeal carcinoma, EurJ Surg Oncol, 2005, 31(5): 555-558.
  • 10Rudland PS, Platt-Higgins A, EI-Tanani M, et al. Prognostic significance of the metastasis-associaled protein osleopontin in human breast cancer. Cancer Res, 2002, 62(12):3417-3427.

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