摘要
目的合成一种新型的5-HT1B/1D受体激动剂。方法以三氮唑为起始原料,经过缩合、还原、肼化、缩合、甲基化5步反应制得利扎曲坦。结果合成收率高(23%),条件温和,目标化合物的结构经元素分析、质谱、氢谱和红外光谱确证,产品纯度可高达99%。
AIM To synthesis a new type 5-HT1B/1D receptor agonist. METHODS Triazole used as start material, through condensation, reduction, hydrazination, condensation and methylation rizatriptan benzoate were synthesed. RESULT Rizatriptan benzoate was synthesed in high yield（23% ） under moderate conditions. The structure of the target compound was comfirmed by element analysis, MS, ^1HNMR and IR. The purity of the final product was more than 99%（HPLC）.
出处
《江苏药学与临床研究》
2006年第6期375-377,共3页
Jiangsu Pharmacertical and Clinical Research
