摘要
目的探讨慢性高原病（CMS）患者肝功能及血清酶的变化。方法选择移居海拔4300m3个月以上的汉族男性青年323名，其中CMS患者87名．为CMS组，其余236名为非CMS组。清晨抽取空腹静脉血检测血清总胆红素（STB）、直接胆红素（SDB）、总蛋白（TP）、清蛋白（BLA）、丙氨酸氨基转换酶（ALT）、门冬氨酸氨基转换酶（AST）、γ-符氨酰转移酶（γ-GT）、碱性磷酸酶（ALP）。以血红蛋白（18g〈血红蛋白〈21g，记0分，血红蛋白≥21g，记3分）及动脉血氧饱和度（动脉血氧饱和度≤85％，记3分）记分。分别以1，2，3分表示轻、中、重度。无CMS总记分为0—5分，轻度为6～10分。中度为11～14分，黄度为15分或更高。结果CMS组较非CMS组STB，AST，ALT，γ—GT增高，有显著性差异（P〈0．05）；TP，BLA降低，有非常显著性差异（P〈0．01），SDB，ALP无统计学差异（P〉0．05）。结论CMS引起肝功能指标及血清酶活性异常，提示CMS伴有多种器官或组织受损。
Objective To explore the liver function and the serum enzyme changes of chronic mountain sickness （CMS） sufferers. Methods A total of 323 youth who stayed at a high altitude of 4,300 meters for more than three months were inspected for serum total biliruhin （STB）, serum direct bilirubin （SDB） , total protein （TP） , albumin （ALB）, alanine aminotransferase （ALT）, aspartate aminotransferase （AST） , γ-glutamyl transferase （γ-GT） and alkalinephosphatase （ ALP ）. Count points on hemoglobin （Hb） and oxygen saturation （SaO2 ） were recorded （ 18g 〈 Hb 〈 21g, getting 0 ponit; Hb ≥ 21 g, getting 3 points） （SaO2 ≤ 85% , getting 3 points）. The patients with a total point amounting to 0 - 5 were considered as non-CMS, and those with a total point more than 5 were considered as CMS. Of the patients, 87 were diagnosed as CMS （ CMS group） and the others were diagnosed as non-CMS （ non-CMS group）. Results STB, AST, ALT and γ-GT in the CMS group increased when compared with that in the non-CMS group, and there was significant difference （ P 〈 0.05 ）. TP and ALB increased significantly in the CMS group than in the non-CMS group （ P 〈 0.01 ）. There was no significant difference in SDB or ALP between the two groups （ P 〉 0.05 ） Conclusion CMS leads to the changes in liver function and serum enzyme activity, which indicates that multiple organs and tissue are damaged.
出处
《临床军医杂志》
CAS
2006年第6期677-678,共2页
Clinical Journal of Medical Officers
关键词
慢性高原病
肝功能
血清酶
chronic high altitude sickness
liver function
serum enzyme
