摘要
出雏一周龄鸡用高于正常免疫剂量５倍的法氏囊疫苗免疫２次．在免疫高峰时宰杀，取出法氏囊，采用超滤法得到了一种分子量小于１万的物质，经检测为多肽和核苷酸的混合物，称为免疫法氏囊活性因子（ＩｍｍｕｎｅＢｕｒｓａｌＡｃｔｉｖｅＦａｃｔｏｒＩＢＡＦ）．理化性质检测类似于转移因子．具有促进淋巴细胞增殖，特别是Ｔ细胞活性的功能，有依赖抗原的特异免疫活性．初步研究表明，具有抑制细菌和抗毒性作用，可望成为一种新的免疫调节剂．
day-old chickens are immunizxed twice with Infectious Bursal Disease Vaccine. The bursa of fabricuis are collected when the immune response has reached a maximum. By ultra-filtration,an active factor with molecular weight less than 10,000 D is obtained. This factor proves to be a complex compound composed of polypeptides and nucleosides. The immune bursal active factor (IBAF) could promote the function of immuno-competent cells. It has bacteriostatic and antitoxic effects. It is showed that IBAF is similar to transfer factors in their chemical & physical properties.
出处
《内蒙古大学学报（自然科学版）》
CAS
CSCD
1996年第6期813-815,共3页
Journal of Inner Mongolia University：Natural Science Edition
基金
内蒙古自然科学基金
