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Graves病甲亢与白细胞介素4基因启动子区-590C/T多态性的相关性研究 被引量：1

The association of the -590C/T polymorphism of interlenkin-4 gene promoter region with Graves' hyperthyroidism
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摘要 探讨中国天津地区汉族人群白细胞介素4(IL-4)基因启动子区-590多态性分布特点及其与Graves病(GD)甲亢发病易感性的关系。结果表明中国天津地区汉族人与不同种族和地区人群的IL-4 (-590)基因多态性分布差异有统计学意义；在天津汉族人群中,GD甲亢与IL-4(-590)基因多态性无相关性。 The - 590 polymorphism of the interleukin-4 （IL-4） gene promoter region and the assoclataon of the IL-4 （-590） polymorphism with Graves＇ hyperthyroidism were investigated in Han people, Tianjin. The results showed that there were signiiicant difference of IL-4 （- 590） gene polymorphism of Han people in Tianjin with other races or areas, and no association of IL-4 （-590） gene polymorphism with Graves＇ hyperthyroidism in Tianjin Han people.
作者 吕元军 樊继援 张鹏 汤绍芳 卫红艳 邱明才
机构地区 天津医科大学总医院内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2006年第6期572-573,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 格雷夫斯病 白细胞介素4 多态现象 遗传 Graves＇ disease Interleukin-4 Polymorphism, genetic
分类号 R581.1 [医药卫生—内分泌]
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参考文献8

  • 1Mulligan CG, Marshall SE, Bunce M, et al. Variation in immunoregulatory genes determine clinical phenotype in common variable immunodeficiency. Genes Immun, 1999,1 : 137-148.
  • 2龚莹,蒋玲,江维岩,张晓黎,赖宏,武传龙.白细胞介素-1α、4、6基因多态性与Graves病的关系[J].中华内分泌代谢杂志,2003,19(6):459-460. 被引量：1
  • 3Hunt PJ, Marshall SE, Weetman AP, et al. Cytokine gene polymorphism in autoimmune thyroid disease. J Clin Endocrinol Metab, 2000,85 : 1984-1988.
  • 4Kitawaki J, Koshiba H, Kitaoka Y, et al. Interferon-gamma gene dinucleotide (CA) repeat and interleukin-4 promoter region ( -590C/T) polymorphisms in Japanese patients with endometriosis. Hum Reprod, 2004,19:1765-1769.
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同被引文献19

  • 1Shiau MY,Huang CN,Yang TP,et al.Cytokine promoter polymor-phisms in Taiwan Residents patients with Graves’disease[J].Clinical Bio-chemistry,2007,40(3-4):213-217.
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  • 3Heward JM,Nithiyananthan R,Allahabadia A,et al.No association ofan interleukin 4 gene promoter polymorphism with Graves’disease inthe United Kingdom[J].J Clin Endocrinol Metab,2001,86(8):3861-3863.
  • 4Chang,Huang CN,Shiau MY.The C-174G promoter polymorphismof the IL-6 gene that affects insulin sensitivity in Caucasians is not in-volved in the pathogenesis of Taiwan Residents type 2 diabetes mellitus[J].Eur Cytokine Netw,2004,15(2):117-119.
  • 5Berkovic MC,Jokic M,Maront J,et al.IL-6-174 C/G polymorphism inthe gastroenteropancreatic neuroendocrine tumors(GEP-NETs)[J].Experimental and Molecular Pathology,2007,83(3):474-479.
  • 6Inoue N,Watanabe M,Morita M,et al.Association of functional poly-morphisms in promoter regions of IL5,IL6 and IL13 genes with devel-opment and prognosis of autoimmune thyroid diseases[J].Clinical andExperimental immunology,2011,163(3):318-323.
  • 7Mehdi Anvari,Omid Khalilzadeh,Alireza Esteghamati,et al.Graves’disease and gene polymorphism of TNF-α,IL-2,IL-6,IL-12,and IFN-γ[J].Endocrine,2010,37(2):344-348.
  • 8M Anvari,O Khalilzadeh,A Esteghamati,et al.Genetic susceptibilityto Graves’ophthalmopathy:the role of polymorphisms in proinflam-matory cytokine genes[J].Eye,2010,24(6):1058-1063.
  • 9Yaron Tomer,Francesca Menconi.Interferon induced thyroiditis[J].Best Practice&Research Clinical Endocrinology&Metabolism,2009,23(6):703.
  • 10Rekha PL,Ishaq M,Valluri V.A differential association of interferon-gamma high-producing allele T and low-producing allele A(+874A/T)with Hashimoto’s thyroiditis and Graves’disease[J].Scandinavi-an Journal of Immunology,2006,64(4):438-443.

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中华内分泌代谢杂志
2006年 第6期

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