摘要
目的:研究归附痛经颗粒的抗痛经作用。方法:用己烯雌酚和缩宫素制造小鼠痛经模型,观察归附痛经颗粒对小鼠痛经模型的影响;用肌动描记技术记录子宫环的收缩曲线,研究归附痛经颗粒对离体大、小鼠子宫收缩的影响。结果:归附痛经颗粒能明显减少雌激素和缩宫素诱发的痛经模型小鼠的扭体次数;抑制离体大鼠和小鼠子宫自发性收缩,抑制缩宫素诱发的离体大鼠子宫的强直收缩。结论:归附痛经颗粒有明显的抗痛经作用。
Objective ：To investigate the anti -dysmenorrheal effects of Guifutongjing granula. Methods ： Dysmenorrheal model was made by ip oxytocin after giving diethylstilbestrol for 12 days, and the effect of Guifutongjing granula on dysmenorrheal mice was observed. Contratile curves of isolated uterine segments was recorded and the effect of Guifutongjing granula on the uterine contraction was compared before and after drug. Results ： Compared to the dysmenorrheal model group, Guifutongjing granula l. 2g/kg,0.6g/kg and 0.3g/kg reduced the twists of the dysmenorrheal mice . Guifutongjing granula 0.03g/L,0. l g/L,0.3g/L, l g/L inhibited the force, frequency and activity of the uterine contraction significantly. Conclusion ：Guifutongjing granula posses an anti -dysmenorrhea effect.
出处
《中药药理与临床》
CAS
CSCD
北大核心
2006年第6期57-58,共2页
Pharmacology and Clinics of Chinese Materia Medica
关键词
归附痛经颗粒
痛经
Guifutongjin granula（归附痛经颗粒）
dysmenorrheal model
