摘要
甲巯咪唑１．４ｍｇ·ｋｇ－１·ｄ－１，阿替洛尔８．２５ｍｇ·ｋｇ－１·ｄ－１分别灌胃，对ＤＬ－Ｔ４诱导的家兔实验性甲亢有良好的缓解作用。阿替洛尔不仅能缓解甲亢的交感神经兴奋现象，而且对血浆Ｔ４也有降低作用，两药合用效果更佳。
Methimazole 1.4 mg· kg-1·d-1 of atenolol 8.25 mg· kg-1· d-1 was used alone and in combination to the hyperthyroid rabbits induced by injecting DL T4.Compared with the saline group,the general conditions of hyperthyroid improved significantly.Atenolol not only improved the sympathetic overactivity,but also decreased serum T4.The effects of two drugs in combination were most effective.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1996年第5期415-417,共3页
Chinese Pharmacological Bulletin
关键词
甲巯咪唑
阿替洛尔
甲亢
药理学
methimazole
atenolol
hyperthyroidism
pharmacodynamics
