摘要
目的观察高压氧联合自由基清除剂对慢性乙型肝炎患者肝纤维化指标的影响。方法选择慢性乙型肝炎患者共72例,随机分为治疗组和对照组(各36例)。对照组给予常规治疗,治疗组则加用高压氧、维生素E与维生素C治疗。观察该疗法对血清肝纤维化指标(透明质酸、层粘蛋白、Ⅲ型前胶原、Ⅳ型胶原)及超声指标(门静脉与脾静脉内径、脾脏长径与厚度)的影响。结果治疗组血清透明质酸、层粘蛋白、Ⅲ型前胶原、Ⅳ型胶原水平与治疗前及对照组比较均显著下降(前者P＜0．05；后3者均P＜0．01),超声结果显示,治疗组门静脉与脾静脉内径、脾脏长径和厚度与治疗前及对照组比较均显著下降(P＜0．05)。结论高压氧联合维生素E与维生素C能改善慢性乙型肝炎患者肝纤维化的血清与超声指标,具有显著的抗肝纤维化作用。
Objective To observe the effects of hyperbaric oxygen （HO） and free radical antagonists （FRA） on liver fibrosis （LF） in chronic hepatitis （CH） patients. Methods Seventy-two CH patients were randomly divided into a HO-FRA group （36 cases） and a control group （36 cases）. The patients in the control group received routine treatment, while patients in the HO-FRA group were treated with hyperbaric oxygen, vitamin E and vitamin C. All patients＇ livers were examined ultrasonically, and liver function and blood fibrosis indices were measured before and after the treatment. Results Compared with those in the control group, the concentrations of blood hyaluronic acid, laminin, precollagen and type Ⅳ collagen were all significantly lower in the HO-FRA group. Ultrasonic imaging showed that the main portal and the splenic vein diameter, and the length and thickness of the spleen had also significantly declined in the HO-FRA group after treatment. Conclusion HO and FRAs can help to stave off liver fibrosis as indicated by blood and ultrasonic fibrosis indices.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2006年第12期831-833,共3页
Chinese Journal of Physical Medicine and Rehabilitation
关键词
慢性乙型肝炎
高压氧
肝纤维化
自由基清除剂
Chronic hepatitis B
Hyperbaric oxygen
Liver fibrosis
Free radical antagonists
