摘要
目的 检测热休克蛋白gp96在喉癌中的表达，并探讨其在喉癌发生发展中的作用。方法 应用免疫组织化学方法检测46例喉癌组织热休克蛋白gp96的表达。结果 T1～2期喉癌患者癌组织与T3-4；期患者比较，T1-2gp96表达的阳性百分率较高，其差异有显著性意义（P〈0．05）。病理学Ⅰ级患者与病理学Ⅱ～Ⅲ级患者比较，Ⅰ级患者癌组织gp96表达的阳性百分率较高，其差异有显著性意义（P〈0．05）。有颈淋巴结转移的患者gp96表达的阳性百分率明显低于无颈淋巴结病理转移的患者（P〈0．01）。热休克蛋白gp96阳性表达与患者年龄（P=0．680）、性剐（P=0．888）、吸烟史（P=0．819）、肿瘤生长部位（P=0．580）无相关性。结论 热休克gp96的表达与喉癌的发生发展密切相关，其表达可以作为判断预后的参考指标之一。
Objective To study the expression and clinical significance of heat shock protein gp96 in laryngeal squamous carcinomas. Methods The expression of gp96 protein in 46 laryngeal squamous carcinomas was detected by immunohistochemical staining and its correlations with clinicalpathological factors were analyzed. Results The expression of gp96 in laryngeal squamous carcinomas of the group T1-2 was stronger than that in the group T3-4. There was remarkable difference between the two groups（P〈 0. 05）. The expression of gp96 in laryngeal squamous carcinomas of pathological stage Ⅰ group was stronger than that in the pathological stage Ⅱ-Ⅲ group. There was striking difference between the two groups（P〈0. 05）. The expression of gp96 in laryngeal squamous carcinomas with lymph node metastasis was significantly lower than that in group without lymph node metastasis（P〈0. 01 ）. The expression of gp96 had no relation with the elements such as age（P = 0. 680）, sex（P = 0. 888）, smoking history（P = 0. 819）, tumor site（P = 0. 580）. Conclusion The results indicate that expression of gp96 protein play a important role in development of laryngeal squamous carcinomas. It can be a mark to predict the prognosis of laryngeal squamous carcinomas.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2006年第12期878-880,共3页
Cancer Research on Prevention and Treatment
关键词
热休克蛋白
GP96
喉癌
Heat shock protein
gp96
Laryngeal squamous carcinoma
