摘要
目的:研究骨质疏松症与血清瘦素和转化生长因子β(TGF-β)浓度的关系。方法:酶联免疫吸附法(ELISA)检测24例骨质疏松症患者血清中瘦素和TGF-β水平,并与正常人对照;计算血清瘦素、TGF-β与骨密度的相关性。结果:骨质疏松症患者TGF-β水平较对照组明显降低(P<0.05),但血清瘦素与对照组无显著差异(P>0.05)。血清TGF-β与骨密度呈正相关,瘦素与骨密度无相关性。结论:TGF-β水平降低可能是骨质疏松症发病的原因之一,而无直接证据表明瘦素水平变化与骨质疏松症发病有相关性。
Objective To explore the relationship between osteoporosis and leptin and transforming growth factor β （TGF - β） levels. Methods Serum leptin and TGF - β in 24 patients with osteoporosis were measured by ELISA, and compared with that in 24 healthy subjects as control. Results The serum TGF - β in the patients with osteoporosis was significantly lower than that in healthy subjects, however, there was no significant difference in serum leptin between patients and healthy subjects. The serum TGF - β was positively correlated with bone mineral density. However, there is not correlation between serum leptin and bone mineral density. Conclusion The decreased level of TGF - β may be one of the causes to precipitate osteoporosis, but there is no direct evidence demonstrating the change of serum leptin is correlated with the pathogonesis of osteoporosls.
出处
《郧阳医学院学报》
2006年第6期331-333,共3页
Journal of Yunyang Medical College
