摘要
目的：探讨胆囊收缩素(CCK)在胆源性胰腺炎(BP)发病中的作用及胆囊结石患者胰腺炎发病率高于肝胆管结石患者的原因。方法：选用辽宁省人民医院2003年10月～2004年10月收治的普外科住院患者及门诊体检中健康人群共163例,既往无肝胆、胰腺病手术史,无梗阻性黄疸病史。将研究对象分为四组：正常对照组、胆囊结石组、肝胆管结石组、BP组。检测其血浆CCK浓度。结果：BP组血浆CCK浓度较正常对照组、肝胆管结石组及胆囊结石组明显升高(P＜0．01),胆囊结石组血浆CCK浓度较对照组及肝胆管结石组明显升高(P＜0．01),正常对照组与肝胆管结石组比较无明显差异。以BP组为病例组,其余三组合为病例对照组,BP病例组与病例对照组按不同的CCK浓度分组后,其组间差异有统计学显著意义(x^2= 11．76、P＜0．01),其相对危险度即OR值随着CCK浓度的增加而递增,即随着CCK浓度的增加患胰腺炎的相对危险性也增加。结论：胆囊结石患者血浆CCK浓度明显高于肝胆管结石患者,是胆囊结石患者胰腺炎发病率较高的原因之一。CCK浓度与BP发病有密切关系,可能是BP病因之一。
Objective： To investigate the action of cholecystokinin in the pathogenesis of biliary pancreatitis and the rea son of higher pancreatitis incidence rate in gallbladder calculus patients than hepatic duct calculus patients. Methods： 163 cases, without liver,gall, pancreas surgical operation history and obstroutive jaundicl listory were selected in Liaoning province people hospital surgery department from 2003.10 to 2004.10. The cases were divided in four groups： Control group, Gallbladder calculus group,hepatic duct calculus group, BP group. Results, The CCK concentration of BP group was obviously higher than other groups （ P〈0.01 ） ;the CCK concentration of gallbladder calculus group was obviously higher than control group and he patic duct calculus group （ P〈0.01 ） ; control group and hepatic duct calculus group had no obvious difference. BP group was set as case group, the other three were set as control group. The case group and the control group had statisticses difference between each levels of CCK concentration （X^2 = 11.76, P〈0.01 ）. Its OR value was increased with the increment of CCK concen tration, namely, the incidence rate of pancreatitis increase along with the increment of CCK concentration. Conclusion： The higher plasma CCK concentration in gallbladder calculus group than hepatic duct calculus group maybe one reason of the higher pancreatitis incidence rate in gallbladder calculus patient than in hepatic duct calculus patient. CCK concentration was closely correlated with the pathogenesis of BP, and it may be one of the etiological factors of BP.
出处
《国际消化病杂志》
CAS
2006年第6期431-432,427,共3页
International Journal of Digestive Diseases
关键词
胆囊收缩素
胆源性胰腺炎
结石
Cholecystokinin
Biliary pancreatitis
Calculus
