摘要
目的了解血清癌胚抗原(CEA)、谷胱苷肽转移酶Pi(glutathione S-transferases,GSTs)在食管癌手术前后变化,探讨其作为食管癌标志物的价值。方法放免法测定50例食管癌患者术前和术后血清中CEA、GST-Pi水平。结果食管癌患者术前血清CEA和GST-Pi水平显著高于正常人(P<0.05),术后均明显降低,术前CEA值与临床分期、肿瘤体积呈正相关,GST-Pi与细胞分化程度呈正相关(P<0.05),联合表达阳性率高于单独表达。结论血清CEA和GST-Pi与食管癌患者的病情、疗效密切相关,具有一定的临床应用价值。
Objective To study the changes of serum CEA and GST Pi before and after operation and their values as markers in esophageal carcino ma, Methods The levels of serum CEA and GST- Pi of 50 cases of esophageal carcinoma patients were measured by radioimmunoassay, Results The levels of serum CEA and GST Pi in preoperative patients were significantly higher than those in postoperative patients The expression rate of GST- Pi was significantly higher in well differentiated carcinoma than that in poorly differentiated carcinoma （ P 〈 0.05） Mean value of CEA was found to be well correlated with the tumor volume, stage Furthermore all the concomitance expression rates were higher than the solely expression rates. Conclusions Both CEA and GST Pi are closely correlated with the condition and curative effect of the esophageal carcinoma patients, and have some value for clinical application.
出处
《医学信息（手术学分册）》
2006年第3期4-6,共3页
Medical Information Operations Sciences Fascicule
基金
河南省科技厅资助项目(001170218)
关键词
食管肿瘤
诊断
肿瘤标志物
esophageal neoplasm diagnosis
tumor marker
