摘要
细胞壁的屏障作用是微生物降低对消毒剂敏感性的普遍机制。消毒剂对细胞膜的作用导致膜的通透性增加,胞内物质泄漏,呼吸链被破坏等。一些消毒剂能直接改变、破坏蛋白质和核酸的结构和功能,但核酸和蛋白质的合成过程可能比结构本身对消毒剂更加敏感。流式细胞仪、单细胞凝胶电泳等新技术的应用将使人们能够更深刻地了解消毒剂的作用机理。
Cell membranes play an important role in resistance of microorganisms to chemical disinfectants. The effects of disinfectants on cell membranes include the alteration of permeability, leakage of intracellular substances, damaging the respiration chains and so on. Though the structures and functions of proteins and DNA altered by some disinfectants, the synthetical processes of them seemed to be more sensitive. Flow cytometry （FCM） and single-cell gel electrophoresis （SCGE） are promising technology which should benefit the investigation of action mode of chemical disinfectants.
出处
《微生物学通报》
CAS
CSCD
北大核心
2006年第6期117-121,共5页
Microbiology China
关键词
化学消毒剂
作用机理
细胞膜
蛋白质
核酸
Chemical disinfectants, Action mode, Cell membrane, Protein, Nucleic acid
