摘要
目的探讨降低重症脑卒中患者并发低白蛋白血症的肠内营养支持方法。方法51例重症脑卒中患者随机分为高蛋白肠内营养制剂组(25例,热氮比=100∶1)和标准肠内营养制剂组(26例,热氮比=130∶1),在相等非蛋白质热量(104.5kJ.kg-1.d-1)摄入条件下,进行不同蛋白质含量肠内营养制剂支持(14天)效果的比较。结果高蛋白肠内营养制剂组发病第7天总蛋白、白蛋白和前白蛋白下降程度低于标准肠内营养制剂组,尤以前白蛋白为著(P<0.05)。发病14天内,APACHEⅡ评分大于19分时,高蛋白肠内营养制剂组低白蛋白血症发生率明显低于标准肠内营养制剂组(P<0.05)。高蛋白肠内营养制剂组1月内生存率有高于标准肠内营养制剂组的趋势。结论重症脑卒中患者应用高蛋白肠内营养制剂可减少低白蛋白血症的发生。
Objective To study the with severe stroke. Methods enteral nutritional approach to decrease the risk of hypoalbumenia in the patients Fifty-one patients with severe stroke were randomly allocated into two groups with high protein enteral nutrition formula （ EN was supplied as Fresubin 750 MCT, NPC：N = 100：1, n = 25） or standard enteral nutrition formula （ EN was supplied as Nutrition Fibre, NPC：N = 130：1, n = 26） respectively. They received equal non-protein-calorie （ 104.5 kJ · kg ^-1· d ^-1 ） in all cases for 14 days. Results Compared to standard nutritional supplementation, high protein nutritional supplementation was associated with a lower incidence of serum protein decrease, including total protein, albumin, and especially prealbumin in pa- tients on the 7th day after stroke （P 〈 0. 05 ）. In the case of APACHE Ⅱ 〉 19, incidence of hypoalbumemia was significantly lower in the high protein group during the 14 days after stroke （ P 〈 0.05 ）. Three-month survival rate was similar between groups, but high protein group tended to have a higher one-month survival rate. Conclusion High protein enteral nutritional formula could reduce the risk of hypoalbumemia significantly in the patients with severe stroke. Thus high protein enteral nutrition is recommended to be used in severe stroke patients.
出处
《中国临床营养杂志》
2006年第6期351-355,共5页
Chinese Journal of Clinical Nutrition
