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核心结合因子a1、骨形成蛋白及骨桥素在小鼠牙周组织发育中的免疫组化定位研究 被引量：1

Expression of Core Binding Factor a1,Bone Morphogenetic Proteins and Osteopontin in the Developing Periodontal Tissues of Mice
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摘要 目的探讨核心结合因子a1、骨形成蛋白和骨桥素3者在小鼠牙周组织发育过程中的时间和空间分布特点、表达意义及它们之间的相互作用。方法用SABC免疫组化法检测3者在出生后不同时期小鼠牙周组织发育中的表达及特点。结果牙齿发育早期,仅骨形成蛋白在牙囊细胞中表达;当牙根开始发育后,3者皆在牙周膜细胞、成牙骨质细胞中表达,但骨形成蛋白在无细胞牙骨质和细胞牙骨质中皆不表达,核心结合因子a1在细胞牙骨质中表达,而骨桥素则在无细胞牙骨质、细胞牙骨质和牙槽骨表面皆呈强阳性表达。结论核心结合因子a1、骨形成蛋白、骨桥素3者皆参与牙周组织的发育,对矿化和生长发育发挥重要作用。 Objective To study the expression and interaction of core binding factor al （Cbfal）, bone morphogenetic proteins （BMPs） and osteopontin （OPN） in the developing periodontal tissues of mice. Methods A mice developing periodontal tissues study model was created histologically by 5-27 day postnatal BALB/c mice, then the immunohistochemical localization of Cbfal, BMPs and OPN in different developing stages were undertaken. Results In early stage of postnatal mice periodontal tissues development, only BMPs expressed in dental follicle cells, though the signal was weak. When root was forming, all of them were expressed in periodontal ligament cells and cementoblasts, while only OPN in acellular cementum, cellular cementum and the surface of alveolar bone, Cbfal only in cellular cementum and BMPs was seen in neither acellular cementum nor cellular cementum. Conclusion Cbfal, BMPs and OPN all involve in the development of periodontal tissues, while OPN is crucial for cementum.
作者 杨丕山 潘克清 李纾 姜波
机构地区 山东大学口腔医院牙周科
出处 《华西口腔医学杂志》 CAS CSCD 北大核心 2006年第6期487-490,共4页 West China Journal of Stomatology
基金 国家自然科学基金资助项目(30371537) 山东省中青年科学家奖励基金资助项目(02BS096)
关键词 核心结合因子A1 骨形成蛋白 骨桥素 core binding factor al： bone morphogenetic proteins： osteopontin
分类号 R78 [医药卫生—口腔医学]
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参考文献11

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共引文献26

同被引文献23

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华西口腔医学杂志
2006年 第6期

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