摘要
目的探讨提高有或无临床症状黄褐斑临床疗效的治疗方法。方法采用随机二阶段交叉对照临床试验研究方案。评价指标为药物效应、药物周期效应、药物后遗效应、皮肤色素、证候疗效、证候疗效与黄褐斑效的关联性。疗效评价采用意愿性评价方法。Ⅰ、Ⅱ阶段疗程各4周。试验方A与对照方B均采用水煎剂型。结果纳入合格自愿受试者106例。试验方交叉前后有效率60.4%显著高于对照方。药物效应与药物周期效应表现显著差异,但是没有出现药物效应与周期效应的交互作用。证候疗效等级与黄褐斑疗效等级没有表现相关性,也没有显示线性趋势。结论调肝益肾权衡湿热、血瘀、痰浊因素的关联性是提高黄褐斑临床疗效的有效途径。
Objective To investigate a superior therapeutic method of chloasma with traditional Chinese medicine （TCM） in women of reproductive age. Methods Two stage cross trial were employed in this study. Valuable labels were included pharmaceutical, periodical and layover effect, clinical symptoms, chloasma area, and correlation of them. Therapeutic course had 4 weeks in the first and the second stage, respectively. Clinic final effect was valued by intentional methodology. Results 106 recipients who fulfilled with inclusion criteria were divided into two groups, therapeutic group and controlling group, respectively. Effect rate of treating group arrived at 60.4% after and before the cross treatment. Therapeutic effect in the treating group was significantly superior to that in the controlling group in the end of clinic final. The pharmaceutical and the periodical effect also manifest markedly difference in this study. But there was not cross effect between the pharmaceutical and periodical effect in each group. The symptom effect has no relation with chloasma area effect, both of them also manifests line relation. Conclusion On the basis of pathological factors such as heat-damp, blood stasis and phlegm, harmonizing liver and reinforcing kidney is good way to improve therapeutic effect.
出处
《中国中医药信息杂志》
CAS
CSCD
2006年第12期16-18,共3页
Chinese Journal of Information on Traditional Chinese Medicine
基金
山西省太原市科技局2001年立项(041307)
关键词
中药
黄褐斑
交叉试验
traditional Chinese medicine
chloasma
cross trial
