摘要
“胀痛消”由左金丸加味组成，临床用于胃肠道疾病取得了较好疗效。本文以胃排空、小肠推进及离体肠管解痉试验观察胀痛消胶囊的胃肠道药理作用。动物雌雄兼用，随机分组，分别观察该药对正常及胃复安、阿托品负荷小鼠胃排空的影响和对正常及新斯的明、肾上腺素负荷小鼠小肠推进的影响，同时观察该药对家兔离体十二指肠自发活动的作用及拮抗氯化乙酰胆碱、氯化钡、组织胺所致离体回肠痉挛的作用。研究结果表明该药明显抑制正常小鼠的胃排空及胃复安所致胃排空加快，对阿托品所致胃排空减慢有协同作用；明显抑制正常小鼠小肠推进，对新斯的明所致小鼠小肠推进加快有明显抑制作用，但对肾上腺素所致小鼠小肠推进减慢没有明显影响；抑制家兔离体十二指肠自发活动以及拮抗氯化乙酰胆碱、氯化钡、组织胺所致家兔回肠痉挛性收缩。以上研究结果提示胀痛消具有调整胃肠运动亢进及缓解胃肠平滑肌痉挛的药理作用。
With phenol red and charcoal powder as marker in stomach and small intestine respectively,the effect of Zhang-Tong-Xiao(ZTX)on gastric emptying function(GEF)and small intestinal propulsive function(SIPF)of the mice were studied,and the contractilitv of isolated rabbitileum was studied as well.The results showed that ZTX capsule had remarkably inhibitory effecton the GEF and SIPF,and also on contractions of isolated ileum induced by submaximal concentrations of acetylcholine(Ach),barium chloride and histamine phosphate;It indicates that ZTXcapsule has the effect of adjusting the hyperactive movement and relieving the spasm of smoothmuscles of the gastrointestinal tract.
出处
《广州中医药大学学报》
CAS
1996年第3期63-65,共3页
Journal of Guangzhou University of Traditional Chinese Medicine
