摘要
以过硫酸铵为引发剂,将羧甲基壳聚糖与甲基丙烯酸进行接枝共聚,讨论了引发剂浓度、羧甲基壳聚糖浓度、甲基丙烯酸浓度对接枝率和接枝效率的影响,当引发剂浓度为4.5×10-3mol/L,甲基丙烯酸浓度为1.5mol/L,羧甲基壳聚糖浓度为5g/L,在50℃反应2.5h,反应的接枝率和接枝效率较高,并用红外光谱对所得的接枝产物进行了表征。以接枝共聚物为载体制备了红霉素药物的缓释片剂,通过测定药物片剂在磷酸盐缓冲溶液(pH=7.4)中的释放速率,表明药物片剂具有缓释作用。
The carboxy methyl chitosan with relatively excellent solubility was firstly prepared through the carboxymethylation of chitosan. Secondly,a copolymer was obtained from graft copolymerization of carboxy methyl chitosan and methacrylic acid using ammonium persulfate as initiator in aqueous medium. It was found that percent of grafting and conversion depended on APS, MAA and carboxy methyl chitosan concentration. The results showed that the optimum conditions were as follows: c(APS)=4.5 mol/L, c(MAA)=1.5 mol/L, ρ(CMC)=5 g/L, grafting temperature 50 ℃ and reaction time 2.5 h. The grafted copolymer was identified by FT-IR. Tablets containing erythromycin were prepared by direct compression of the copolymer and drug. The release rates of drugs in phosphate buffer (pH=7.4) were examined in vitro, and it showed that erythromycin in tablets was released slowly.
出处
《新技术新工艺》
2006年第11期50-52,共3页
New Technology & New Process
