摘要
目的评价6个月和8个月全程间歇短化方案治疗新发涂阳肺结核患者5年复发率的情况。方法276例新发涂阳肺结核患者被随机分成两组,其中130例采用6个月短化方案治疗,146例接受8个月短化方案,所有病人完成治疗且疗末痰菌阴转后,再进行5年随访观察。结果276例中实检人数256例(92.8%),16例(5.8%)失访,4例(1.4%)死亡。细菌学总复发率为5.1%,6个月和8个月方案细菌学复发率分别为4.9%,5.2%,两组差异无显著性(P>0.05)。放射学总恶化率为4.3%,总吸收率为39.5%,总稳定率为56.3%,6个月和8个月放射学恶化率分别为4.1%、4.5%,两组差异无显著性(P>0.05)。结论6个月和8个月短化方案5年疗效观察效果相近,但6个月短化方案服药次数少,治疗费用低,值得推广。
Objective To assess the long- term therapeutic efficacy of 6 - month and 8 - month intermittent regimens and observe the difference of relapse rate. Methods 276 new smear - positive patients were selected and randomly divided into 6 - month group consisted of 130 cases and 8 - month group consisted of 146 cases based on the chemotherapeutic duration. All patients completed full course of treatment and were followed up for 5 years. Results Of 276 patients, 16（5.8 % ） changed the house or defaulted, 4（ 1.4% ） died and 256（92.8 % ） were actually followed up. The total bacteriologic relapse rate was 5.1%, The relapse rates in 6 - month and 8 - month groups were 4.9 % and 5.2 % respectively, without significant difference between the two groups （ P 〉 0.05）. The total absorption rate was 39.5% and total stable rate was 56.3% by checking the chest films during and at the end of the follow up. The focus worsening rate was 4.3 %, 6 - month and 8 - month groups were 4.1% and 4.5 respectively without statistical significance （P 〉 0.05）. Conclusion The 6 - month chemotherapy can achieve the same effect as that of the 8 - month one. Sputum negative conversion was the main index of assessing therapeutic efficacy while focus morphological change can be used as reference.
出处
《中国热带医学》
CAS
2006年第12期2150-2150,2159,共2页
China Tropical Medicine
关键词
结核
肺
新发涂阳
短程化疗
复发
Tuberculosis
Lung
New smear-positive
Short-course chemotherapy
Relapse
