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经颅多普勒在卒中溶栓治疗中的应用 被引量：3

The Application of Transcranial Doppler in Stroke Thrombolytic Therapy
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摘要 经颅多普勒在重组组织型纤溶酶原激活剂静脉溶栓和动静脉联合溶栓中可用于诊断和监测,判断动脉闭塞部位,选择适合溶栓的病例,监测动脉再通情况。经颅低频超声持续监测具有辅助溶栓的作用,目前在临床使用频率上还有争议。经颅超声辅以微气泡对比剂可进一步增强溶栓效果。 Transcranial Doppler can be used for diagnosing, monitoring, identifying the site of arterial occlusion, selecting appropriate cases for thrombolysis, and monitoring arterial recanalization during intravenotts thrombolysis, and intra-arterial and intravenous thrombolysis with recombinant tissue plasminogen activator, The continuous monitoring of low frequency transcranial ultrasound has the effect of assisted thrombolysis; however, there are still controversies on the frequencies used in clinical practice. Transcranial Doppler assisted with microbubble contrast agent may further enhance the effect of thrombolysis.
作者 薛爽 周宝玉 王国相
机构地区 北京中日友好医院神经内科
出处 《国际脑血管病杂志》 2006年第10期741-744,共4页 International Journal of Cerebrovascular Diseases
关键词 经颅多普勒 卒中 溶栓 重组组织型纤溶酶原激活剂 transcranial Doppler stroke thrombolysis recombinant tissue plasminogen activator
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献23

  • 1Alexandrov AV,Demchuk AM,Wein TH,et al.Yield of transcranial Doppler in acute cerebral ischemia.Stroke,1999,30:1604-1609.
  • 2Domchuk AM,Burgin WS,Christou I,et al.Thrombolysis in brain ischemia (TIBI) transcranial Doppler flow grades predict clinical severity,early recovery,and mortality in patients treated with intravenous tissue plasminogen activator.Stroke,2001,32:89-93.
  • 3Alexandrov AV,Domchuk AM,Felberg RA,et al.High rate of complete recanalization and dramatic clinical recovery during tPA infusion when continuously monitored with 2-MHz transcranial doppler monitoring.Stroke,2000,31:610-614.
  • 4薛爽,刘兴洲.缺血性脑卒中静脉内溶栓治疗的TCD检测[J].中华老年心脑血管病杂志,2002,4(3):212-214. 被引量：2
  • 5Manelfe C,LarrUE V,Kummer RV,et al.Association of hyperdense middle cerebral artery sign with clinical outcome in patients treated with tissue plasminogen activator.Stroke,1999,30:769 -772.
  • 6Baracchini C,Manara R,Ermani M,et al.The quest for early predictors of stroke evolution can TCD be a guiding light? Stroke,2000,31:2942-2947.
  • 7Alexandrov AV,Felberg RA,Demchuk AM,et al.Deterioration following spontaneous improvement:sonographic findings in patients with acutely resolving symptoms of cerebral ischemia.Stroke,2000,31:915 -919.
  • 8Burgin WS,Malkoff M,Felberg RA,et al.Transcranial Doppler ultrasound criteria for recanalization after thrombolysis for middle cerebral artery stroke.Stroke,2000,31:1128-1132.
  • 9Lewandowski CA,Frankel M,Tomsick TA,et al.Combined intravenous and intra-arterial r-TPA versus intra-arterial therapy of acute ischemic stroke:Energecy Management of Stroke (EMS) Bridging Trial.Stroke,1999,30:2598-2605.
  • 10The IMS Study Investigators.Combined intravenous and intra-arterial recanalization for acute ischemic stroke:the Interventional Management of Stroke Study.Stroke,2004,35:904 -911.

二级参考文献41

  • 1Porter TR,Kricsfeld D,Li S, et al.Comparison of d- dimer activity and residual particle size produced following thrombus disrupton by perfluorocarbon containing microbubbles versus urokinase in the presence of low frequency ultrasound. J Am Coll Cardiol,1
  • 2Bimbaum Y,Luo H, Nagai T, et al. Noninvasive in vivo clot disso- lution without a thrombolytic drug: Recanalization of thrombosed iliofemoral art-eries by transcutaneous ultrasound combined with intravenous infusion of microbubbles. Circulation, 1998,97 (
  • 3Tohomas R P, Feng X, Karen K. Intravenous perfluoropropane - exposed sonicated dextrose albumin produces myocardial ultrasound contrast that correlates with coronary blood flow. J Am Soc Echocardiography, 1995,8: 710 ～ 718.
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  • 6Evan CU, Terry OM. Therapeutic applications of micro - bubbles. European J Radiology,2002,42:160 - 168.
  • 7Apfel RE, Holland CK. Gauging the likelihood of cavitation from short -pulse,long- duty cycle diagnostic ultrasound. Ultrasound Med Biol, 1991,17(2): 179 - 185.
  • 8Culp WC, Porter TR, Xie F, et al. Microbubble potentiated ultrasound as a method of declotting thronbosed dialysis grafts: experimental study in dogs.Cardiovasc Intervent Radiol, 2001 ,24(6) :407 - 412.
  • 9Culp WC, Erdem E. Microbubble Potentiated Ultrasound as a Method of Stroke Therapy in a Pig Model: Preliminary Findings. J Vascular Interventional Radiology,2003,14(11) :1 433- 1 436.
  • 10Karsufumi M,Isao K. Enhancement of ultrasound- accelerated thrombolysis by echo contrast agents:dependence on microbubble structure. Ultrasound in Med Biol,1999,25(9):1 431 - 1 437.

共引文献7

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国际脑血管病杂志
2006年 第10期

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