摘要
为探讨西替利嗪治疗支气管哮喘的可能性与可靠性，作者采用随机单盲法将４０例缓解期支气管哮喘患者随机分为治疗组（３０例）和对照组（１０例），治疗组口服西替利嗪５ｍｇ，对照组口服维生素Ｃ０．１ｇ，分别于服药前及服药后半小时、１小时对气道阻力（Ｒａｗ）和最大呼气流量－容积曲线（ＭＥＦＶ）进行了测定。结果：治疗组患者口服西替利嗪后半小时，气道阻力、肺功能指标有不同程度改善，其中Ｒａｗ明显降低，比气道传导率（ｓＧａｗ）、用力肺活量（ＦＶＣ）增高，１小时后改善更为显著。对照组Ｒａｗ和肺功能改变不大，说明西替利嗪能明显减轻支气管哮喘患者Ｒａｗ，改善其肺功能。
The objective of this study was to investigate the possible anti asthma role of Cetirizine. Forty asthmatics were randomly divided into two groups. The experimental group had 30 patients. Among them were 10 patients with simple asthma, 5 patients complicated by mild emphysema, 6 patients complicated by moderate emphysema and 9 patients complicated by severe emphysema. Vit C (control) group had 10 cases, including 2 cases of simple asthma, 6 cases complicated by mild emphysema and 2 cases complicated by moderate emphysema. All patients had a single oral dose of 5 mg Cetirizine or 0.1g Vit C blindly. Before and 0.5, 1 hour after their medicines, the resistance of airway (Raw), sGaw and MEFV were examined in all patients on 6200 Plethysmograph. The measured values showed a significant improvement of Raw and sGaw after administration of Cetirizine. In half an hour after Cetirizine, the Raw decreased by 20.408%, and sGaw increased by 28.249%. In one hour after Cetirizine, Raw further decreased by 24.34% and sGaw increased by 41.153% ( P<0.001 ). The FVC in MEFV increased by 4.96% (P<0.02) in one hour after Cetirizine, but other parameters in MEFV curve (PEF, FEV 1, MMEF) had no significant changes. All parameters in control group had no significant changes ( P>0.05) . The results indicate that Cetirizine could decrease Raw in asthmatics, improve their lung ventilatory function. Cetirizine is a new H receptor antagonist usually used as anti inflammatory and allergy suppresion medication. It is shown that Cetirizine is a promising anti asthma agent in treating bronchial asthma.
出处
《华西医科大学学报》
CSCD
1996年第4期411-414,共4页
Journal of West China University of Medical Sciences
关键词
哮喘
西替利嗪
气道阻力
药物疗法
Asthma Cetirizine Resistance of airway Maximal expiratory flow volume curve
