摘要
目的:探讨术前和术后多时相介入化疗在可切除性胰腺癌综合治疗中的临床应用价值。方法:将术前判断可切除性胰头癌病人38例随机进入多时相介入治疗组(试验组)和术后介入治疗组(对照组),通过血清肿瘤标志物的改变和对标本肿瘤组织相关基因检测观察术前介入的疗效和作用机制;随访两组病人的生存期和无瘤生存时间,以及肝转移的发生率比较两种不同治疗方式的疗效。结果:术前介入治疗组部分甲基化相关基因(MBD1、E2F5和RB)的表达明显下降、细胞凋亡比值(bax/bcl-2)明显增加、血清肿瘤标志物水平显著降低,病人疼痛明显缓解(P<0.05);对照组肝转移的发生率明显高于试验组。结论:术前和术后多时相介入化疗能明显抑制胰腺癌肿瘤细胞生长和促进肿瘤细胞凋亡,减少肝转移的发生,是胰腺癌综合治疗的有效措施之一。
Objective To verify the effect of preoperative and postoperative multiple-phase interventional chemotherapy in respectable pancreatic carcinoma. Methods Thirty-eight patients with resectable pancreatic cancer were divided into two groups： the treatment group received multiple-phase interventional chemotherapy and the control group received postoperative interventional chemotherapy only. The serum tumor markers and tumor-related gene expression in resected tumor samples were examined to evaluate the effects of preoperative interventional chemotherapy. The survival time, tumor-free survival time and the rate of liver metastasis were also analyzed in these two groups. Results The ratio of bax/ bcl-2 increased, and the levels of serum tumor markers and the expressions of nm23-h1, MBD1, E2F5 and RB decreased remarkably in the treatment group in comparison with the control group （P〈0.05）. The disease-related symptoms improved obviously in the treatmemt group with lower rate of liver metastasis. No significant difference in survival time was observed between these two groups. Conclusions The multiple-phase interventional chemotherapy constitutes an effective method in the muhi-modality therapy of pancreatic carcinoma by enhancing tumor cell apoptosis, inhibition of tumor growth and reduction of liver metastasis.
出处
《外科理论与实践》
2006年第6期492-495,共4页
Journal of Surgery Concepts & Practice
基金
上海市科委临床医学重点项目(054119504)
关键词
胰腺肿瘤
介入治疗
综合疗法
Pancreatic cancer
Multiple-phase interventional chemotherapy
Combined therapy
