摘要
对１４例肠病相关的Ｔ细胞性淋巴瘤（ＥＡＴＣＬ）进行临床和病理分析，并对其免疫表型进行研究。结果显示：临床上ＥＡＴＣＬ多见于青壮年男性，常有发热、贫血、慢性腹痛、腹泻及便血，半数以上病例在病程中出现肠穿孔；３系细胞减少，肝脾肿大，浅表淋巴结肿大较少见。病理上以回、结肠多发溃疡为特征，无肿块形成；镜下为异型淋巴细胞散在浸润，常有大片坏死，肠粘膜萎缩，血管浸润及嗜上皮现象；单核组织细胞反应明显常为其特点之一。免疫组化标记１４例均为Ｔ细胞阳性。文中对如何从临床和病理上提高ＥＡＴＣＬ的诊断率进行了讨论。另外，本研究发现在ＨＥ切片中有明显吞噬功能的组织细胞样细胞其免疫标记也为Ｔ细胞阳性。
The clinical and pathological data of l4 cases of enteropathy-associated T-cell lymphoma(EAT-CL)were studied and were investigated for the immunophenotypes. The results showed:Clinically,EATCLoccured more frequently in young male adults,usually with fever, anemia,abdominal pain and diarrhea. A-cute intestinal perforation happened in most of them in the course of disease;Only a few cases had tumefac-tion of liver,spleen,superficial lymph nodes and diminution in number of platelets,leukocytes and erythro-cytes. In pathological morphology,in the ileum and colon, there are multiple ulcers,but no mass.Under mi-croscopic observation,EATCL was consisted of pleomorphic lymphoma cells with massive necrosis,atrophyof mucosa epithelium,vascular infiItration and epitheliotropism;Immunohistochemical studies demonstrat-ed that all of them were UCHL-l positive. We discussed, also,how to improve the rate of dignosis of EAT-CL clinically and pathologically. Additionally,we found that the histiocyte-like cells with phagocytoticfunction in HE sections were T-cell positive immunologically.
出处
《第一军医大学学报》
CSCD
1996年第4期282-284,共3页
Journal of First Military Medical University
