摘要
目的探讨声敏剂在声动力治疗过程中于超声相互作用的反应机理。方法通过实验研究不同条件下声敏剂镓卟啉(ATX-70)溶液在超声作用下的产物来推断其作用机理。结果在超声作用并且有氧参与条件下,ATX-70降低了超声空化过程中产生的.OH的浓度,而增加了溶液中1O2和O2-的浓度,并且ATX-70的分子结构并不发生改变。结论在声动力治疗中,声敏剂ATX-70与超声空化产生的处于激发态的.OH作用,转移.OH的能量,然后被激发的ATX-70将能量转移给溶液中溶解的O2,产生能够杀死肿瘤的1O2和O2-,而在治疗过程中其自身结构并不改变。
Objective To study the work mechanism of sonosensitiver named ATX-70 in sonodynamic therapy （SDT）. Methods The mechanism of SDT was analyzed by studying the reactions between ultrasound and the gallium-porphyrin analogue ATX-70 experimentally. Results When ultrasound appeared, the ATX-70 reduced the excitated ·OH which was produced by cavitation. And made the concentration of ^1O2 and O2 increased, which were thought as the killer of tumour cells. However, in the process, the ATX-70 doesn＇t change. Conclusion In the process of SDT, ATX-70 takes away the energy of the excitated · OH produced by cavitation and is excitated, then transfers the energy to the dissolved oxygen in the solution to produce ^-O2 and O2^- , which can kill the turmor cells. Results show that ATX-70 is an effective sonosensitiver in SDT.
出处
《中国介入影像与治疗学》
CSCD
2006年第6期454-458,共5页
Chinese Journal of Interventional Imaging and Therapy
