摘要
目的观察冠心病稳定性心绞痛患者血浆髓过氧化物酶(MPO)水平。方法选择2个种族的573例已行冠状动脉造影患者,其中295例为冠心病稳定性心绞痛组(SAP组),278例非冠心病稳定性心绞痛为对照组。分别测血浆MPO水平及空腹血浆总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、甘油三酯、葡萄糖、空腹血浆胰岛素、脂联素、纤维蛋白原、超敏C反应蛋白和Ⅶ因子浓度,并采用Spearman法对冠心病稳定性心绞痛的危险因素进行相关性分析。结果MPO水平SAP组为126．3(95．8～160．2)mg/L,对照组为123．6(97．4～150．0)mg/L,差异无统计学意义(P＞0．05)；黑人男性、白人男性、黑人女性及白人女性MPO水平分别为119．6(94．8～146．9)、124．6(99．9～154．6)、124．0(93．3～152．3)mg/L及127．5(95．3～159．8)mg/L,4组比较差异无统计学意义(P＞0．05)。MPO水平与Ⅶ因子(r=0．251,P＜0．01)、空腹血糖(r=0．095,P＜0．05)、甘油三酯(r=0．186,P＜0．01)、总胆固醇(r=0．081,P＜0．05)、超敏C反应蛋白(r=0．123,P＜0．01)和纤维蛋白原(r=0．077,P＜0．01)呈正相关；与脂联素(r=0．115,P＜0．01)呈负相关。结论冠心病稳定性心绞痛患者血浆MPO水平未升高,不是冠心病稳定性心绞痛患者的预测因子,且在性别、种族间无差异。
Objective To investigate the plasma level change of myeloperoxidase （MPO） in patients suffering from stable angina pectoris. Methods Five hundred and seventy three patients underwent elective coronary angiography in a bi-racial cohort study, which included 295 patients with stable angina pectoris（SAP） and 278 subjects served as control. Plasma level of MPO and traditional risk factors of coronary artery disease （CAD） were measured. Results MPO levels did not differ significantly between control group and SAP group[126.3 （95.8-160.2） mg/L vs 123.6 （97.4-150.0） mg/L P〉0.05]. MPO levels were similar across ethnicity and gender[black male 119.6（94.8-146.9） mg/L, white male 124.6 （99.9 - 154.6） mg/L, black female 124.0 （ 93.3 - 152.3 ） mg/L and white female 127.5（95.3-159.8）mg/L], and were correlated positively with the levels of Ⅶ factor （r= 0.251,P〈0. 01）, fasting plasma glucose （r=0.095,P〈0.05）,triglyceride （r=0.186,P〈0.01）, total cholesterol （r=0. 081, P〈0.05）, high-sensitivity C-reactive protein （r=0. 123, P〈0.01） and fibrinogenlevels （ r=0.077, P〈0.01）, negatively correlated with adiponectin level （r=-0.115, P〈0. 01）. Conclusions Plasma MPO level is not elevated in patients with SAP. This suggests that MPO is not a characteristic feature of SAP. There are also no significant relationships between different genders and between different ethnicities.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2006年第11期829-831,共3页
Chinese Journal of Geriatrics
