摘要
AIM： Recently it has been reported that granulocyte colony stimulating factor （G-CSF） can induce hypercoagulability in healthy bone marrow donors. It is conceivable that the induction of a prothrombotic state in a recipient of an organ graft with already impaired perfusion might cause further deterioration in the transplanted organ. This study evaluated whether G-CSF treatment worsens liver perfusion following liver transplantation in the rat model. METHODS： A non-arterialized rat liver transplantation model was employed to evaluate the effect of G-CSF treatment on the liver in a syngeneic and allogeneic strain combination. Study outcomes included survival time and liver damage as investigated by liver enzymes and liver histology. Observation times were 1 d, 1 wk and 12 wk. RESULTS： Rats treated with G-CSF had increased incidence and severity of biliary damage following liver transplantation. In these animals, hepatocellular necrosis was accentuated in the centrilobular region. These lesions are indicative of impaired perfusion in G-CSF treated animals. CONCLUSION： G-CSF should be used with caution in recipients of liver transplantation, as treatment might enhance preexisting, undetected perfusion problems and ultimately lead to ischemia induced biliary complications .
瞄准：最近，粒细胞殖民地刺激因素(G-CSF ) 罐头在健康骨髓施主导致 hypercoagulability，这被报导了。prothrombotic 的正式就职与已经损害的灌注在机关接枝的一个接受者声明原因可能在移植机关推进恶化，是想得到的。这研究评估了 G-CSF 治疗是否变得更坏在老鼠的肝灌注追随者肝移植当模特儿。方法：一个化为动脉血得非的老鼠肝移植模特儿被雇用在 syngeneic 和 allogeneic 紧张联合在肝上评估 G-CSF 治疗的效果。学习结果包括了由肝酶和肝组织学调查了的生存时间和肝损坏。观察时间是 1 d， 1 wk 和 12 wk。结果：与 G-CSF 对待的老鼠增加了胆汁的损坏追随者肝移植的发生和严厉。在这些动物，肝细胞坏死在小叶中心区域被加重。这些损害在 G-CSF 的损害灌注是指示的对待的动物。结论：当治疗可能提高先存在的、未被发现的灌注问题并且最终导致局部缺血， G-CSF 应该在肝移植的接受者小心地被使用导致的胆汁的复杂并发症。
基金
Supported by the Deutsche Forschungsgemeinschaft (KFO 117/1) and the IFORES Research Program, University Hospital Essen
