摘要
目的观察动物肠切除吻合、肝叶切除术后局部使用医用创面封闭胶的防肠漏、肝创面止血的作用。方法24只幼猪随机分为两组,每组12只。实验组分别在肠吻合口、肝创面涂上医用创面封闭胶,对照组涂生理盐水,术后观察肝切口止血时间、肠吻合口破裂压、胶存留情况、吻合口组织羟脯氨酸、病理组织学检查。结果实验组肝止血时间明显短于对照组,术后d1吻合口破裂压明显高于对照组,术后d14,d28两组吻合口破裂压无显著性差异(P>0.05),术后未见明显胶存留,两组肠吻合口组织羟脯氨酸无显著性差异(P>0.05)。病理组织学检查显示实验组纤维瘢痕明显减轻。结论医用创面封闭胶有止血、防止肠吻合口漏的作用,未见明显副作用。
[Objective]To evaluate the effect of medical sealant glue used in intestinal anastomoses and hepatectomy for preventing intestinal anastomotic leakage and hepatorrhagia. [Methods]All animals were divided into two groups;in experiment group, medical sealant glue was used on the surface of anastomotic site and liver, in control group, normal saline was used. Liver bleeding time, anastomotic bursting pressure （ABP）, glue remains, histologic changes of anastomotic stoma and liver, the contents of oxyproline hydroxyproline of anastomotic stoma were observed. [Results]Liver bleeding time of experimental group was shorter than that of control group, ABP was obviously higher in experimental group than that of control group in day 1 postoperatively, but no obvious difference between the two groups in day 14,28 postoperatively. There were no glue remains in day 14,28 postoperatively. The contents of oxyproline, hydroxyproline on anastomotic stoma had no ,significant difference between the two groups, anastomotic scar of experimental group was less than that of control group. [Conclusion]Medical sealant glue has the effect of stoping bleeding and preventing intestinal anastomotie leakage,without side effect.
出处
《医学临床研究》
CAS
2006年第11期1739-1741,共3页
Journal of Clinical Research
关键词
胶剂
创伤和损伤
动物
实验
COLLOIDS
wounds and injuries
animals,laboratory
