摘要
Cushing综合征是因下丘脑—垂体—肾上腺轴调控失常而致肾上腺分泌过多糖皮质激素所致病症的总和,目前的药物治疗靶点包括控制下丘脑—垂体的促肾上腺皮质激素的合成和分泌、阻断肾上腺异常表达受体、抑制肾上腺糖皮质激素的合成和分泌,以及阻断外周糖皮质激素的效应。近年来,随着研究的深入,循证医学为传统的治疗方法提供了临床证据,越来越多的潜在药物靶点被发现,本文就Cushing综合征的药物治疗进展作相关综述。
Cushing＇s syndrome is caused by disregulation of hypothalamus-pituitary-adrenal gland （HPA） axis and the excessive secretion of cortisol from the adrenal cortex. The present pharmacologic managements include inhibitors of adrenocorticotropic hormone （ACTH） secretion, ACTH receptor antagonists, and inhibitors of glucocorticoid synthesis or secretion. Nowadays, with the further studies, evidence-based medicine provides many clinical evidences for traditional therapy, and more and more drug targets have been found. This review is just about the recent studies about drug therapy of Cushing＇s syndrome.
出处
《国际内分泌代谢杂志》
2006年第6期421-423,共3页
International Journal of Endocrinology and Metabolism
基金
上海交通大学医学院博士点基金
