摘要
目的:探讨乳腺癌X线摄影钙化征象与雌激素受体(ER)、孕激素受体(PR)及人表皮生长因子相关基因(CerbB-2/HER-2/neu)表达的相关性。方法:回顾性分析87例术后病理诊断为乳腺癌患者的双乳腺X线轴位、斜位片,记录乳腺癌钙化情况,术后标本行免疫组织化学染色测定肿瘤细胞ER、PR及CerbB-2表达情况,分析乳腺癌钙化灶与上述因素的关系。结果:乳腺癌钙化灶与ER、PR表达无相关性,而乳腺癌钙化灶与CerbB-2的表达有相关性。结论:乳腺癌钙化征象与分子生物学指标CerbB-2之间存在一定的相关性。乳腺癌X线摄影从一定程度上反映了癌细胞的生物学行为和预后,为临床治疗方案的选择提供客观依据。
Objective ： To evaluate the relationship between the malignant calcification and the expression of ER,PR and CerbB-2 in breast cancer. Methods： Mammography was performed in 87 cases of patients with breast cancer, Mammographic calcification of breast cancer were retrospectively studied, ER,PR and CerbB-2 expression of the specimens of the patients were examined with immunohistochemistry. The relationship between the malignant calcification and the expression of ER,PR and CerbB-2 was analyzed, Results tPositive expression of ER and PR was not significantly correlated with the malignant calcification of breast cancer, while the expression level of CerbB-2 was negatively correlated with the findings of calcification in breast cancer. Conclusion：There was a considerable extent of correlationship between the malignant calcifica- tion and the expression of CerbB-2 in breast cancer. Mammographic calcification of breast cancer not only reflected the tumor biological behavior and prognosis,but also provided information for clinical treatment planning of the relative cases as. well.
出处
《放射学实践》
2006年第11期1142-1144,共3页
Radiologic Practice
