摘要
作者用青石棉、苯并（ａ）芘、青石棉加苯并（ａ）芘对大鼠经气管注入染尘，在染尘后９０、１８０、２７０、３６０和５４０天时动态观察肺组织超氧化物歧化酶（ＳＯＤ）和脂质过氧化物（ＬＰＯ）及ＳＯＤ／ＬＰＯ比值的变化。结果表明，青石棉加苯并（ａ）芘可诱发大鼠肺内Ｏ－２自由基反应增强，脂质过氧化反应增高，ＬＰＯ含量升高，同时抗氧化能力降低，ＳＯＤ／ＬＰＯ比值降低。
Wistar rats were divided into 4 groups: control group, Cro group, B(a) p group and Cro plus B(a)p group. Samples of lung tissue were collected 90, 180, 270, 360 and 540 days after the third time of intratracheal. The superoxide dismutase (SOD) acitivity, the level of lipid peroxide (LPO) and the ratio of SOD/LPO were observed. The results indicated that there was a synergistic action of Cro. and B(a) p.
出处
《华西医科大学学报》
CSCD
1996年第3期266-269,共4页
Journal of West China University of Medical Sciences
基金
国家教委高校博士点专项科研基金
CMB资助
