摘要
目的为了解支气管肺泡洗出液（ＢＡＬＦ）细胞学在闭塞性细支气管炎伴机化性肺炎（ＢＯＯＰ）和普通型间质性肺炎（ＵＩＰ）的特征。方法分别对经病理学证实的、不吸烟的７例ＢＯＯＰ和７例ＵＩＰ的ＢＡＬＦ中细胞分类计数和Ｔ淋巴细胞亚群进行了测定。结果与ＵＩＰ组相比，ＢＯＯＰ组的淋巴细胞比率、ＣＤ＋８细胞比率均明显升高，而ＣＤ＋４／ＣＤ＋８比率明显降低（Ｐ均＜０．０１）；与ＢＯＯＰ组相比，ＵＩＰ组的中性粒细胞明显升高（Ｐ＜０．０５）。结论测定ＢＡＬＦ中的细胞分类计数和Ｔ淋巴细胞亚群，对鉴别ＢＯＯＰ和ＵＩＰ有指导作用，对研究二者不同的病理生理学过程。
ObjectiveBOOPisadiseaseentityproposedbyeplerin1985,andUIPisconsideredanim-portantdiseasetobediferentiatedfromBOOP.Theaimofthisstudywastoidentifycharacteristicfea-turesinBALFsamplesofpatientswithBOOPandUIP.MethodsDiferentialcelcountandT-celsub-populationoftheBALFobtainedfrom7patientswithBOOPand7patientswithUIP,bothhistological-lyverified,weredetermined.ResultsInBOOPpatientstheratiooflymphocytesandtheCD+8celinBALFweresignificantlyhigherandCD+4/CD+8ratiowassignificantlylowerthanthoseoftheUIPpatients(P<0.01).InUIPpatientstheratioofneutrophilsinBALFwassignificantlyhigh-erthanthatoftheBOOP-patients(P<0.05).ConclusionsCytologicalexaminationofBALFiseffectiveindifferentiatingBOOPfromUIPanditcanprovideusefulinformationaboutbothdiferentpathogeneticprocessesofthetwoen-tities.
出处
《中华结核和呼吸杂志》
CSCD
北大核心
1996年第5期276-278,共3页
Chinese Journal of Tuberculosis and Respiratory Diseases
基金
广西壮族自治区教委资助课题
关键词
支气管肺泡
细支气管炎
BronchoalveolarlavagefluidPneumoniaPulmonaryfibrosisBronchioli-tisobliteranswithorganizingpnumonia
