摘要
目的探讨初诊2型糖尿病患者接受胰岛素泵短期强化治疗后及1年后的临床效果。方法使用胰岛素泵对38例初诊2型糖尿病患者进行为期3周的持续胰岛素皮下输注(CSII)强化治疗,比较治疗前后及1年后血糖(空腹血糖和餐后2h血糖)、胰岛素、C肽、糖化血红蛋白(HbA1c)、胰岛β细胞功能(HOMA—β)和胰岛素抵抗指数(HOMA—IR)等。结果治疗后的空腹及餐后血糖达到良好控制;C肽较治疗前显著升高(P<0．05);HOMA—IR和HOMA—β明显改善(P<0．05)。结论胰岛素泵CSⅡ强化治疗能在短时间内达到理想血糖控制,有利于胰岛β细胞功能的恢复,部分患者能够获得较长时间的血糖控制。
Objective To observe the effects of intensive insulin therapy in newly diagnosed type 2 diabetic patients. Methods The 38 patients were treated by continuous subcutaneous insulin infusion （CSⅡ） with insulin pump.Fasting plasma glucose （FPG）, 2-hour postprandial glucose （2hPG）,glycosylated hemoglobin Ale （HbA1c）,insulin and C-peptide were measured. HOMA-（ and HOMA-IR were calculated. Results After 3 weeks of intensive treatment the excellent control of FPG and 2hPG in all the patients were achieved, the level of C-peptide was significantly higher than that before treatment （P〈0.05）. HOMA-IR were decreased and HOMA-β were increased significantly（P〈0.05）.Conehlsion The excellent glycomic control and improvement of β cell function can be induced by short-term CS Ⅱ intensive therapy in newly diagnosed type 2 diabetic patients.Some of patients can acquire longer improvement.
出处
《实用医药杂志》
2006年第11期1297-1299,共3页
Practical Journal of Medicine & Pharmacy
关键词
2型糖尿病
胰岛素泵
治疗
Type 2 diabetes mellitus Insulin therapy Insulin pump
