摘要
目的探讨儿童嗜酸性淋巴肉芽肿(ELG)的临床特点和诊治方法,以提高对本病的认识。方法回顾性分析5例ELG患儿的临床特征、实验室检查、病理、治疗及疗效,并进行相关文献复习。结果ELG 5例均为男童,主要表现为多发性皮肤软组织肿块和淋巴结大,其中1例并肾病综合征,2例有反复湿疹样皮疹,1例2次发生喘息性支气管炎,患儿均无肝脾大,生长发育良好。最初单纯化疗4例均复发,经配合局部放疗或加用环孢素(CsA)等治疗后未复发。结论儿童ELG临床及病理特点与成人相似,但儿童发病较少。单纯化疗易复发,配合放疗、手术、应用CsA等综合治疗可提高疗效。
Objective To explore the clinical features and treatment of eosinophilic lymphoid granuloma （ELG） in children, in order to incresse understanding of the disease. Methods Clinical features, laboratory examination, pathological examination, treatment and therapeutic effect of 5 patients with ELG were retrospectively studied, and the related literature were reviewed. Results Five cases were all boys. They all presented many subcutaneous swellings and lymphadenopathy. A case among them was associated with nephrotic syndrome, and 2 cases had the complication of eczema repeatedly, and 1 case ever had 2 times episodes of asthmatiform bronchitis. All of them had no hepatomegaly and splenomegaly, physically was well developed. Only chemotherapy was supplied to all the patients. During the course of therapy, 4 eases among them recurred. After that, they were successfully treated with irradiation of lesion or cyclosporine（CsA）. Conclusions ELG in children is as same as adult in clinicopathological features. It tends recur only with chemotherapy. We can get better curative effect with the synthetic treatment of chemotherapy, radiotherapy, operation or oral CsA and so on.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2006年第21期1489-1490,1508,共3页
Journal of Applied Clinical Pediatrics
关键词
嗜酸性淋巴肉芽肿
儿童
诊断
治疗
eosinophilic lymphoid granuloma
child
diagnosis
therapy
