摘要
应用９３７０ＭＨｚ微波脉冲式辐射豚鼠耳区，两组动物的辐射剂量分别为８９２、４３３１ｍＷ／ｃｍ２，观察耳蜗血管纹的Ｎａ＋—Ｋ＋—ＡＴＰ酶的活性变化，并与正常组动物对照比较。经医学图像分析仪对所摄底片血管纹辉度进行定量分析，结果表明：正常对照组Ｎａ＋—Ｋ＋—ＡＴＰ酶的均值与标准差为５９．１９±３．９０；８９２ｍＷ／ｃｍ２组为６１．５８±５．２６；４３３１ｍＷ／ｃｍ２组为２７．０４±２．０５。前两组比较并无显著性差异（Ｐ＞０．０５），而４３３１ｍＷ／ｃｍ２组与对照组及８９２ｍＷ／ｃｍ２组之间的差异均显著（Ｐ＜０．０１）。提示８９２ｍＷ／ｃｍ２的辐射强度为安全剂量；４３３１ｍＷ／ｃｍ２强度为有害剂量，可在损害内耳结构的同时抑制细胞内Ｎａ＋—Ｋ＋—ＡＴＰ酶的活性。
Using 9370 MHz microwave irradiation,the effect on Na+-K+-ATPase activity of cochlear striae vascularis in guinea pigs was studied。 The animals were divided into 3 groups:the normal control group, the two other groups in which the animals underwent the microwave irradiation with power density of 892 mW/cm2 and 4331 mW/cm2,respectively。By imaging processor,the analysed results showed that:the mean value and SD of Na+ K+ ATPase of normal control group was of 59.19±3.90, 61.58±5.26 of 892mW/cm2 irradiated group and 27.04±2.06 of 4331mW/cm2irradiated group, The t test showed no significant difference between the normal control group and 892mW/cm2 irradiated group. However,a significant difference(P<0.01) was presented between 4331mW/cm2 group and the other two groups, respectively. It suggested that the microwave irradiation with power density of 892 mW/cm2 was safe in the use of both clinical and experimental, but,the power density of 4331 mW/cm2 was evidently of harmful dose in use, which could inhibited the activity of Na+ K+ ATPase while the structures of inner ear damaged。 The mechanism of the inhibition was also discussed.
出处
《上海第二医科大学学报》
CSCD
1996年第5期305-307,共3页
Acta Universitatis Medicinalis Secondae Shanghai
基金
国家自然科学基金
