摘要
七氟烷作为一种吸入麻醉剂已广泛应用于临床。近年来有关七氟烷对心脏和脑等器官功能影响的研究表明：七氟烷对脑组织和心肌具有保护作用。七氟烷可有效地维持脑血管的自主调节功能和血管对二氯化碳的反应性，并通过减少突触间兴奋性神经递质．激活钾通道及阻断钠通道等表现出脑缺氧损伤保护作用。与其他吸入麻醉剂相比．七氟烷不仅对心血管系统的生理干扰作用较小；同时还有显著的心肌缺血缺氧后损伤保护效应。其可能机制是改善心肌氯供／氧需比例．侧支循环及降低多形核细胞的黏附等间接保护作用；通过缺血预处理样作用和再灌注过程中的直接保护作用。
Given the current clinical interest, the effects of sevoflurane on organ system are popular, particularly on the brain and heart. Sevoflurane may provide neuroprotection and cardioprotection. The vessel reaction on carbon dioxide partial pressure and cerebral auto regulation are maintained during sevoflurane anesthesia. To sevoflurane neuroprotective effect, a reduction of ischaemia-induced efflux of excitatory amino acids and activating potassium channels whilst blocking sodium channels have been reported. Sevoflurane protects the heart against ischaemia and reperfusion injury by many mechanisms, including both improving oxygen supply/demand ratio and collateral blood flow and reduction of polymorphonuclear（PMN） cell adherence, through preconditioning and direct protection during reperfusion.
出处
《麻醉与监护论坛》
2006年第5期276-279,共4页
Forum of Anesthesia and Monitoring
关键词
七氟烷
脑保护
心肌保护
Sevoflurane
Neuroprotection
Cardioprotection
