摘要
目的:探讨急性冠脉综合征(ACS)患者血浆脑钠肽(BNP)浓度的变化及临床意义。方法:选择稳定型心绞痛(SA)患者20例,不稳定型心绞痛(UA)、急性心肌梗死(AMI)患者各30例。急性冠状动脉综合征(ACS)包括SAP和UAP。测定其血浆BNP浓度,与正常对照组20例相比较,分析各组间有无显著性差异。结果:血浆BNP浓度在正常对照组、SAP组、UAP组、AMI组分别为38.15±11.26pg/ml、41.92±13.37pg/ml、308.54±97.34pg/ml、736.29±103.63pg/ml,SAP组与正常对照组血浆BNP浓度无显著性差异(P>0.05)。UAP组、AMI组与正常对照组、SAP组血浆BNP浓度具有显著性差异,P均<0.001。AMI组与UA组血浆BNP浓度具有显著性差异(P<0.001)。结论:ACS时血浆BNP浓度明显升高,AMI患者血浆BNP浓度高于UA患者,表明心肌缺血是BNP释放的重要刺激因素,其在一定程度上可以反映冠心病心肌缺血的严重程度。
Objective：To investigate the change of plasma brain natriuretic peptide（BNP） in patients with acute coronary syndrome（ACS） and its significance. Methods：20 patients with stable angina pectoris（SA）, 30 unstable angina pectoris（VA）, 30 acute myocardial infarction（AMI） were selected. ACS included SAP and UAP. The level of plasma BNP was detected and compared with normal control group（ n = 20）, then the diffences among groups were analyzed. Results：The level of plasma BNP was respectively 38.15 ±11.26pg/ml,41.92 ± 13.37pg/ml,308.54 ± 97.34pg/ml and 736.29 ± 103.63pg/ml in normal control group, SAP group, UAP group and AMI group. Compared with normanl controls, The level of BNP showed no difference in SAP group （P 〉 0.05）. The difference between UAP,AMI group and normal contral, SAP gruop was significant（ P 〈 0. 001）. There was group （P 〉 0.05）. The difference between UAP , AMI group and normal control, SAP group was significant （P 〈 0.001）. There was also difference in level of BNP between AMI group and UA group （P 〈 0. 001）. Conclusion： The level of BNP increases in ACS,and is higher in AMI than in UA,which indicates myocardial ischemia was stimulating factor for releasing BNP. BNP may reflect the degree of myocardial ischemia in ACS.
出处
《内蒙古医学杂志》
2006年第10期886-887,共2页
Inner Mongolia Medical Journal
关键词
脑钠肽
冠心病
急性冠状动脉综合征
Brain natriuretic peptide（BNP）
Coronary heart disease
Acute coronary syndrome（ACS）
