摘要
目的:观察前列腺素E1(PGE1)对毛支患儿血浆血栓素β2(TXβ2)、6-酮前列腺素F1 a(6-keto-PGF1 a)水平的影响。方法:检测32例毛支患儿急性期及PGE1治疗后血浆TXβ2、6-keto-PGF1 a水平,并以20例健康儿作为对照。结果:毛支患儿急性期TXβ2、TXβ2/6-keto-PGF1 a比值显著高于正常对照组,有显著性差异(P均<0.01),6-keto-PGF1 a于急性期明显降低,与正常对照组相比有显著差异(P<0.01)。PGE1治疗后血浆TXβ2、TXβ2/6-keto-PGF1 a比值显著低于治疗前,有显著性差异(P均<0.01);与正常对照组相比无显著性差异。PGE1治疗后6-keto-PGF1 a升高,但与治疗前组比无显著性差异,P>0.05。结论:前列腺素E1对毛细支气管炎治疗有效,其作用机理与抑制血栓素A2合成有关。
Objective： To investigate the effect of PGE1 on levels of TXβ2 and 6 - keto - PGF1 a in plasma of children with bronchiolitis. Methods： The changes of TXβ2 and 6 - keto - PGF1a in plasma of 32 children with bronchiolitis treated by PGE1 were detected and compared with those of 20 normal children. Results： The ratio of TXI32 to 6 - keto - PGF1 a and the levels of 6 - keto - PGF1 a in acute period of bronchilitis group were much higher than those in normal group （ P 〈0.01, P 〈0.01 ） ; The levels of TXβ2 in plasma ofbronchiolitis group and the ratio of TXβ to 6 - keto - PGF1a were much lower by treated with PGE1 （ P 〈 0. 01 ）, but there were not obvious differ- ence compared with those in normal group ; The levels of 6 - keto - PGFIa in plasma were much higher, but there were not obvious difference compared with that normal group. Conclusion： PGE1 can effectively treat bronchiolitis, which may act through prohibiting TXβ2 synthesis.
出处
《中国妇幼保健》
CAS
北大核心
2006年第21期2963-2964,共2页
Maternal and Child Health Care of China
