摘要
目的:了解广东省肇庆市端州区新生儿脐血红细胞葡萄糖-6-磷酸脱氢酶(G-6-PD)缺乏的发生率。方法:2 236例活产新生儿出生后即取脐血,采用定量法测定红细胞G-6-PD/6-PGD的比值,低于1.0者为G-6-PD缺乏。结果:G-6-PD缺乏的患儿152例,总发生率为6.79%。其中男129例,发生率为10.34%;女23例,发生率为2.32%,男性发生率明显高于女性(2χ=90.03,P<0.001)。结论:脐血G-6-PD活性筛查,能比较准确地检测出G-6-PD缺乏患儿,指导临床对其并发症进行早期干预,避免智力低下等后遗症的发生,提高人口素质。
Objective： To explore the incidence of G -6 - PD deficiency in Duanzhou District, Zhaoqing, Guangdong province. Methods： Cord blood was obtained in 2 236 cases of live births to measure G - 6 - PD/6 - PGD ratio. Results： Two hundred and sixtyfive cases were diagnosed as G -6 -PD deficiency giving an incidence of 6. 79%. The incidence in male （10. 34% , 129/1 247） was significantly higher than that in female （2. 32%, 23/989） （P 〈0. 001 ） . Conclusion： Screening of G -6 - PD can detect infants who suffer from G - 6 - PD deficiency, which can provide earlier precautions for clinicians.
出处
《中国妇幼保健》
CAS
北大核心
2006年第21期2959-2960,共2页
Maternal and Child Health Care of China
关键词
葡萄糖-6-磷酸脱氢酶缺乏
新生儿筛查
脐血
Glucose phosphate dehydrogenase deficiency
Neonatal screening
Fetal blood
