摘要
综述了亚乙烯基核苷衍生物(1,N6-亚乙烯基腺苷,N2,3-亚乙烯基腺苷,1,N2-亚乙烯基鸟苷,N2,3-亚乙烯基鸟苷, 1,N6-亚乙烯基脱氧腺苷,1,N2-亚乙烯基-2’-脱氧鸟苷,N2,3-亚乙烯基-2’-脱氧鸟苷)的研究进展,讨论了其荧光性质和生物活性的应用,展望了新型荧光扩环核苷衍生物的合成及其在荧光探针和高效药物筛选方面的研究前景．
The development of etheno-nucleoside derivatives, including 1,N^6-ethenoadenosine, N^2,3-ethenoadenosine, 1,N^2-ethenoguanosine, N2,3-ethenoguanosine, 1,N^6-etheno-deoxyadenosine, 1,N^2-etheno-2＇- deoxyguanosine and N^2,3-etheno-2＇-deoxyguanosine is reviewed. Their fluorescent and biochemical properties are discussed. The study prospects of synthesis of novel fluorescent ring expansion nucleoside derivatives and their application to fluorescent probes and high though-put screening for drug are suggested.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2006年第11期1457-1462,共6页
Chinese Journal of Organic Chemistry
基金
山东省中青年奖励基金(No.02BS019)资助项目.
关键词
亚乙烯基核苷
合成
荧光
生化性质
综述
ethenonucleoside
synthesis
fluorescence
biochemical property
review
