摘要
目的观察加味附子理中汤对27例马兜铃酸肾病(Aristolochic acid nephropathy,AAN)患者肾功能及临床症状的影响。方法以加味附子理中汤水煎服,每日1剂,4周为1个疗程,共治疗9个疗程。观察治疗前后血尿素氮(BUN)、血肌酐(SCr)、内生肌酐清除率(CCr)、24h尿蛋白定量(Upro)、尿N-乙酰-β-D-氨基葡萄糖苷酶(尿NAG酶)、尿渗透压、红细胞(RBC)、血色素(HB),以及以以以以、以以乏力、以以以以、以以以以、面色以白、以酸膝软等临床症状的变化情况。结果与治疗前比较,BUN、SCr、CCr、24hUpro、尿NAG酶、尿渗透压有显著差异(P<0.05);治疗后患者肾功能得到明显改善;同时,临床症状得到缓解,与治疗前症状积分比较,以以以以、以以乏力、以以以以、以酸膝软、以以以以、面色以白等差异有显著性意力(P<0.05),临床总有效率为74.07%。结论加味附子理中汤对AAN有较好的治疗作用。
Objective To investigate the effects on the renal function and the clinical symptoms of patients with aristolochic acid nephropathy （AAN） treated with the Chinese herbal medicine, Jiaweifuzilizhongtang. Method Twenty-seven patients with AAN were treated with Jiaweifuzilizhongtang. The indexes, such as blood urea nitrogen （BUN）, serum creatinine （SCr）, endogenous creatinine clearance rate （CCr）, twenty-four-hour proteinuria quantitate （24 h Upo）, β-N-acetyglocosamidase （NAG）, Urine Osmol （Uosm）, erythrocyte （RBC）, hemoglobin （HB） and so on, were observed before and after treatment, and the score of patients＇ symptoms including aversion to cold and cold limbs, lassitude and weakness, poor appetite and anorexia, nausea and vomiting, pale complexion, was also calculated. Result Compared with that of treatment bebore, the renal function of patients after treatment was significantly improved （P〈0.05） according to the indexes of BUN, SCr, CCr, 24 h Upro, NAG, Uosm, RBC and HB; Meanwhile, the score of clinical symptoms after treatment was obviously different （P〈0.05） from that of treatment before, and the total clinical effective rate was 74.07%. Conclusion Chinese herbal medicine, Jiweifuzilizhongtang, can effectively treat the patients with aristolochic acid nephropathy （AAN）.
出处
《中国中医药信息杂志》
CAS
CSCD
2006年第11期17-18,22,共3页
Chinese Journal of Information on Traditional Chinese Medicine
基金
2005年广西卫生厅重点课题(200518)
关键词
加味附子理中汤
马兜铃酸肾病
临床探讨
Jiaweifuzilizhongtang
aristolochic acid nephropathy
clinical research
