摘要
核酸适配子是采用指数富集配体的系统进化(SELEX)技术从随机单链寡核苷酸库中筛选出的能与靶物质高特异性、高亲和力结合的配体,其特性在很多方面优于抗体,在分子识别研究中具有重要价值,可用于靶物质的测定、阻断靶物质的生物活性,在肿瘤的诊断和治疗中有着广阔的应用前景。
Nucleic acid aptamers are ligands with high specificity and affinity for their targets, which are screened from large oligonucleotide pools by the SELEX technology. Their characteristics are superior to antibodies in many aspects, which make them important in the research of recognition of molecules. They can be used to determine the levels and inhibit the bioactivity of their targets. There＇re broad application prospects for aptamers in the diagnosis and treatment of tumor.
出处
《国际肿瘤学杂志》
CAS
2006年第10期756-759,共4页
Journal of International Oncology
关键词
肿瘤
诊断
治疗
核酸适配子
Neoplasms
Diagnosis
Therapy
Nucleic acid aptamers
