摘要
目的:探讨氨氯地平片(络活喜)加复方丹参滴丸对自发性高血压大鼠(SHR)血管壁重塑的干预。方法:将32只10周龄雄性SHR随机分成空白对照组(SHRC)、阴性对照组(SHRNS)、阳性对照组(SHRA)和治疗组(SHRA+D)四组,每组8只。空白对照组未作治疗即测定各指标,并与8只同周龄Wistar鼠比较。除空白对照组外,后三组分别经生理盐水、络活喜、络活喜加复方丹参滴丸治疗8周后处死,测定各项指标。结果:与wistar组比较,空白对照组及阴性对照组血压明显增高、管腔增大、血管壁明显增厚,尤以血管中层平滑肌细胞(VSMC)肥大为主;经治疗后,阳性对照组及治疗组血压明显降低,血管壁增厚得到遏制;阳性对照组与治疗组之间比较,治疗组血管壁变薄更明显,但无统计学意义。结论:络活喜通过降低血压遏制SHR血管壁重塑,加复方丹参滴丸治疗能进一步遏制血管壁重塑,但可能表现为时效关系。
Objective：To investigate the intervention of amlodipine combined with composite salviae dropping pill on vascu lar remodeling of spontaneously hypertensive rats. Methods：32 SHRs were randomly divided into 4 groups with 8 SHRs each. Some indexes of the blank contrast group （ SHRc ） were detected with any treatment and compared with those of 8 Wistar rats. The negative contrast group （SHRNs） , the positive group （SHRA ） and the treatment group （SHRA ＋D ） were injected by sodium chloride, amlodipine, and amlodipine combined with composite salviae dropping pill respectively. After 8 week treatment, all rats were executed and indexes detected. Results：Compared with those of Wistar rats, the blood pressure, lumen of blood vessel, thickness of vascular wall of SHRc and SHRNs increased obviously. Especially VSMC became hypertrophy. After treatment, the blood pressure of SHRA and SHRA ＋ D significantly decreased. The thickness of vascular wall was also restrained. The vascular wall of SHRA was thinner than that of SHRA＋D. The difference had no statistic meaning. Conclusion ：Amlodipine can restrain vascular remodeling by decreasing the blood pressure. The additional composite salviae dropping pill have the further intervention function, which maybe show the time-benefit relation.
出处
《浙江中西医结合杂志》
2006年第11期665-666,668,共3页
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
关键词
自发性高血压大鼠
血管壁重塑
络活喜
复方丹参滴丸
spontaneously hypertensive rat, vascular remodeling, amlodipine, amlodipine, combined with composite salviae dropping pill
