摘要
目的:探讨胰岛素样生长因子-1(IGF-1)、胰岛素(IN S)与妊娠期高血压疾病发病的关系。方法:选取30例妊娠期高血压疾病患者(疾病组)及10例同期住院待产正常孕妇(对照组)血清及胎盘标本,采用放射免疫方法(R IA)检测两组血清中IGF-1、IN S浓度水平,采用免疫组织化学SABC法检测IGF-1在两组胎盘中的表达情况。结果:疾病组血清中IGF-1水平明显低于对照组且随着疾病的严重程度增加而降低;疾病组血清IN S水平明显高于对照组,且疾病组血清中IGF-1与IN S呈显著负相关;疾病组与对照组胎盘组织IGF-1表达部位无差异,在疾病组表达明显降低。胎盘IGF-1表达强度与血清IGF-1水平存在直线正相关。结论:胰岛素样生长因子-1、胰岛素参与妊娠期高血压疾病的发病。
Objective： To study changes of levels of insulin--growth factor--1 （IGF--1） and insulin （INS） in maternal serum and IGF--1 expression of placenta in hypertensive disorder complicating pregnancy and their clinical significance. Methods： This study included 30 women with hypertensive disorder complicating pregnancy as study group and 10 normal pregnant women as control group. Radioimmunoassay （RIA） was used to measure IGF--1 and INS levels. The localization of IGF--1 protein was analyzed by using immunohistochemical staining. SPSS 11.5 was used, and P〈 0.05was considered statistically significant. Results： The IGF--1 level in maternal serum in study group was significantly reduced compared with that in control group （P 〈 0.05） , while the INS level in study group was significantly increased compared with that in control group （P 〈 0.05） , with a negalive correlation between the IGF--1 level and INS level in serum of study group. The IGF--1 protein expression was significantly decreased in study group compared with uncomplicated case in term placentas （P 〈0.05） . Conclusion; Both IGF--1 and INS in serum may involve in lhe progression of hypertensive disorder complicating pregnancy.
出处
《黑龙江医药科学》
2006年第5期16-17,共2页
Heilongjiang Medicine and Pharmacy
