摘要
目的研究双侧扣带回+双侧内囊前肢组合对顽固性强迫症的治疗作用。方法采用立体定向方法,运用双侧扣带回+双侧内囊前肢的靶点组合、射频热凝治疗顽固性强迫症26例。在手术前和手术后3个月、6个月及2年分别采用Yale-Brown强迫量表(Y-BOCS)进行评估。结果26例强迫症中,手术后各时间段测定的Y-BOCS评分、强迫思维评分和强迫行为评分与手术前比较均有统计学差异。结论双侧扣带回+双侧内囊前肢的多靶点组合治疗,对顽固性强迫症有明显的治疗作用。
Objective To evaluate the therapeutic effect of stereotactic lesions of bilateral callosal gyrus and bilateral anterior limb of internal capsule on intractable obsessive—compulsive disorder. Methods 26 cases with intractable obsessive—compulsive disorder were treated with srereotactic location techniques. CRW stereotactic apparatus and CT were used to define nucleus location. The targets of the lesion, both bilateral callosal gyrus and bilateral anterior limb of internal capsule,were verified by intra-operative impedance test. The lesions were generated by radiofrequency at 75℃ for 60 seconds. Pre and post operative Yale-Brown Obsessive Compulsive Scale （Y-BOCS） was evaluated by psychiatrists. Results Before,3 months after,6 months after and 2 years after the operation,the total scores of Y-BOCS were 26. 12±7. 66,14.23±5. 91,14. 54±6.00,16.46±6. 24, respectively. At the same time, the obsessive agent—scores were 12. 85±4. 59,6.19±3. 14,5.46±3. 60,6.35±3, 27,and the compulsive agent-scores were 13, 27±5.65, 8.04±4. 47,9. 08±4. 19,10. 12±4. 72. The total scores of Y-BOCS, the obsessive agent-scores and the compulsive agent—scores in all phases after surgery were significantly lower than those before operation,respectively. Conclusion Stereotactic lesions of bilateral callosal gyrus and bilateral anterior limb of internal capsule is a very effective therapy for refractory obsessive-compulsive disorders. It is promised to improve the symptoms of intractable obsessive-compulsive disorder.
出处
《立体定向和功能性神经外科杂志》
2006年第5期257-259,共3页
Chinese Journal of Stereotactic and Functional Neurosurgery
关键词
立体定向
强迫症
扣带回
内囊前肢
Stereotactic techniques
Obsessive-compulsive disorder
Callosal gyrus
Anterior limb of internal capsule
