摘要
目的本实验探讨长期大量饮酒对大鼠性功能的影响。方法将30只雄性大鼠随机分为对照组,20%酒精剂量组和40%酒精剂量组。分别以生理盐水、20%和40%食用酒精各2mL给大鼠灌胃,每日1次。3个月后,观察各组大鼠性行为和药物诱发阴茎勃起的变化;用酶放大物理发光仪测定各组大鼠血清睾酮的含量;测定阴茎平滑肌中一氧化氮合成酶的总量。结果与对照组相比,20%酒精剂量组和40%酒精剂量组大鼠性行为、血清睾酮含量和阴茎组织中一氧化氮合成酶活性有统计学意义(P<0.05),40%酒精剂量组大鼠的药物诱发阴茎勃起实验也受到抑制(P<0.05)。结论大鼠长期大量饮酒后性功能障碍,其机制与血浆睾酮含量降低,阴茎组织中一氧化氮合成酶活性降低有关。
[ Objective ] To investigate the effects of long terra and excessive intake of ethanol on sexual function of the rats. [Methods] Thirty adult male Wistar rats were randomly divided into throe groups： the control group, 20% ethanol group and 40% ethanol group. 0.9% natric chloride.20% and 40% ethanol solution were administered with a dose of 2ml through gastric tubes in the rats every day. Three monthes later, the effects of ethanol on sexual function were studied by sexual behavior, the number of apomorphine-induced penile erection, testosterone in the sera and nitric oxide synthase（NOS） in the penis. [Results] Compared with the control group, sexual behavior, testosterone in the sera and NOS activity in the penis of 20% ethanol group and 40% ethanol group were inhibited significantly （P 〈0.05）. The number of apomorphine-induced penile erection was also decroased notably in 40% ethanol group（P 〈0.05）. [Conclusion] Long terra and excessive intake of ethanol can induce sexual dysfunction in rats. The decline of testosterone in the sera and NOS in the penis may be respensible for it.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2006年第19期2881-2883,2887,共4页
China Journal of Modern Medicine
关键词
酒精
睾酮
性功能
一氧化氮合成酶
ethanol
testosterone
sexual function
nitric oxide synthase
