摘要
７／８肾切除大鼠３．５月后，血色素和血浆白蛋白均明显下降（Ｐ＜０．０１）；血尿素氮、肌酐、胆固醇、甘油三脂和２４ｈ尿蛋白定量明显增高（Ｐ＜０．０１）；微机图象定量分析显示肾小球面积、系膜硬化程度和纤维素样渗出面积明显增加（Ｐ＜０．０１）。而尿激酶治疗后则可减轻肾切除后肾小球的肥大及系膜硬化，减轻纤维素样沉积，从而可减轻肾切除大鼠血清尿素氮、肌酐的升高，减少蛋白尿的排泄量。本研究提示：凝血机制紊乱可能是导致肾小球硬化的重要因素，而尿激酶通过减轻肾小球内凝血系统紊乱，故可延缓肾小球硬化的发展。
An animal model of chronic glomerulosclerosis was induced by 7/8 nephrectomy in Wistar rat.Theresults showed that hemoglobin and plasma albumin were significantly decreased and the blood level of BUN,Cr,cholesterol,triglyceride and urinary protein output were significantly increased in the experimental ratsComputerized quantitative analysis of glomerular area demonstrated that the area of glomerulus, mesangialsclerosis and fibrin-like exudation were significantly increased.The levels of BUN and Cr and proteinuria de-creased significantly after UK treatment.The area of glomerulus,mesangial sclerosis and fibrin-like exudationdecreased significantly in the UK treated group. It is concluded that the renal histological lesion on experimen-tal rats may be improved by treatment with UK.
出处
《军医进修学院学报》
CAS
1996年第1期10-12,共3页
Academic Journal of Pla Postgraduate Medical School
关键词
尿激酶类
肾功能衰竭
肾小球硬化
大鼠
urokinase
therapeutic use
kidney failure,chronic
glomerulosclerosis
rats
