摘要
目的:探讨运动对衰退骨组织的结构和功能的影响作用及与衰老的关系。方法:40只12月龄清洁级雄性昆明小鼠,随机分成老年对照组、10min运动组、20min运动组和40min运动组,分别实施12周不同的运动方案,10只3月龄和10只7月龄清洁级雄性昆明小鼠分别作为青年和成年对照组。采用固体物理密度仪测定骨密度,骨生物力学测量仪测定最大载荷、最大应力、模量和能量。结果:1)运动各组与老年对照组相比,运动各组间相比ALP均无显著性差异;与老年对照组相比,10min、20min运动组骨密度升高(P=0.067,P=0.071);2)与老年对照组分别相比,青年对照组、成年对照组最大载荷、最大应力和模量均显著升高(P<0.01);运动各组与老年对照组分别相比,20min运动组的最大载荷、最大应力、模量和能量值均升高于老年对照组(P<0.01、P<0.05),运动各组组间相比,20min运动组的最大载荷和最大应力高于10min运动组(P<0.01、P<0.05),也高于40min运动组(P<0.05)。结论:1)适宜负荷的游泳训练可促进骨的矿化;2)游泳对骨生物力学指标的影响与运动负荷有关,适度负荷的的游泳运动可较好改善骨生物力学综合性能,运动负荷不足或负荷过大都无法优化运动效应;3)适宜的运动能显著改善骨代谢,改善骨的结构和功能,促进骨生物力学指标的优化,这对延缓骨细胞衰老和骨组织的功能衰减具有积极意义。
The purpose of this study was to discuss the effects of exercise on the tissue structure and function and related to aging. Forty sanitary male KM mice aged at twelve months were randomly divided into four groups,Aged control group,exercise group with ten minutes,exercise group with twenty minutes and exercise group with forty minutes. All of groups were carried on twelve weeks exercise. Ten mice aged at three month and ten mice aged at seven month were taken as junior and senior control group respectively. Bone mineral density （BMD） and biomechanical index were measured by using the solid physic density instrument and biomechanical instrument respectively. Main biomechanical index included maximal load and stress, modulus and energy. The result showed that comparing with aged control group ,there was no significant difference on ALP in each exercise group. The level of BMD was high in exercise group with ten and twenty minutes respectively. Maximal load, stress and modulus were significantly higher in junior and adult control group than that of aged control group respectively. Comparing with aged control group, maximal load and stress, modulus and energy supply were higher in exercise group with twenty minutes. It concluded that suitable intensity swimming training could improve bone mineralization. The effects of exercise on biomechanical index of bone related to exercise intensity and suitable intensity exercise could improve the synthetic function of bone biomechanics. Less or more exercise intensity could not win a good effect. The suitable exercise intensity was benefit to structure, function and metabolism of bone tissue. These benefits played a good role in the retard of cell aging and function degradation of bone.
出处
《中国体育科技》
CSSCI
北大核心
2006年第5期140-143,共4页
China Sport Science and Technology
基金
上海市重点学科建设项目(T0901)资助。
关键词
衰老
运动
骨代谢
骨密度
生物力学
鼠
动物实验
aging
exercise
bone metabolism
bone mineral density
biomechanics
rat
animal experiment
